| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | OrbiMed Advisors Samuel Isaly | 4,127,987 | $52,590,554 | +84% | 0.97% |
| 2. | Boxer Capital Aaron Davis And Christopher Fuglesang | 3,149,310 | $40,122,209 | 3.02% | |
| 3. | Biotechnology Value Fund / BVF Inc Mark Lampert | 2,350,000 | $29,939,000 | 0.77% | |
| 4. | RA Capital Management Peter Kolchinsky | 2,332,457 | $29,715,502 | 0.26% | |
| 5. | Point72 Asset Management Steve Cohen | 1,173,396 | $14,949,065 | 0.02% |