| No. | Hedge Fund | Shares | Value | Activity | % Port | 
|---|---|---|---|---|---|
| 1. | Farallon Capital Thomas Steyer  |  6,172,006 | $341,126,772 | +2% | 1.47% | 
| 2. | Deep Track Capital David Kroin  |  3,245,899 | $179,400,838 | +9% | 5.75% | 
| 3. | Biotechnology Value Fund / BVF Inc Mark Lampert  |  3,211,041 | $177,474,236 | +25% | 6.34% | 
| 4. | Adage Capital Management Phill Gross And Robert Atchinson  |  1,092,262 | $60,369,321 | +218% | 0.1% | 
| 5. | Commodore Capital Egen Atkinson And Michael Kramarz  |  1,075,000 | $59,415,250 | 4.19% | 
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 | 
|---|---|---|---|---|---|---|
| $6.70 | 12,000 | $80,400.00 | 15,310 | 2020-03-12 | Filing | |
| $5.70 | 8,000 | $45,620.00 | 8,000 | 2019-12-03 | Filing | |
| $5.13 | 30,000 | $153,900.00 | 49,500 | 2019-12-03 | Filing | |
| $5.09 | 562 | $2,860.58 | 1,175 | 2019-12-03 | Filing | |
| $5.10 | 613 | $3,126.30 | 613 | 2019-12-03 | Filing | 
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 | 
|---|---|---|---|---|---|---|
| $87.81 | 8,000 | $702,480.00 | 5,130 | 2025-10-10 | Filing | |
| $69.25 | 4,000 | $277,000.00 | 13,130 | 2025-10-10 | Filing | |
| $64.25 | 4,000 | $257,000.00 | 5,130 | 2025-09-22 | Filing | |
| $59.25 | 4,000 | $237,000.00 | 9,130 | 2025-08-27 | Filing | |
| $54.78 | 10,415 | $570,533.70 | 520,603 | 2025-07-25 | Filing | 
| No. | Name | Shares | Value | % Port | 
|---|---|---|---|---|
| 1. | 363,261 | $24,131,429 | 0% | |
| 2. | 305,419 | $20,288,984 | 0.02% | |
| 3. | 143,060 | $9,503,476 | 1.8% | |
| 4. | 90,317 | $5,999,757 | 0.01% | |
| 5. | 89,171 | $5,923,629 | 0.05% |