| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Suvretta Capital Management Aaron Cowen | 1,135,406 | $173,512,745 | -2% | 3.17% |
| 2. | Biotechnology Value Fund / BVF Inc Mark Lampert | 672,789 | $102,815,615 | -30% | 2.63% |
| 3. | Woodline Partners Michael Rockefeller And Karl Kroeker | 317,517 | $48,522,948 | 0.15% | |
| 4. | OrbiMed Advisors Samuel Isaly | 292,360 | $44,678,455 | +118% | 0.83% |
| 5. | Siren L.L.C. Raymond Debbane | 257,485 | $39,348,858 | 0.8% |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $112.30 | 445 | $49,973.50 | 187,616 | 2026-03-30 | Filing | |
| $125.00 | 4,000 | $500,000.00 | 187,171 | 2026-02-27 | Filing | |
| $125.00 | 2,400 | $300,000.00 | 47,812 | 2026-02-27 | Filing | |
| $20.27 | 2,490 | $50,472.30 | 13,516 | 2025-04-09 | Filing | |
| $20.13 | 2,500 | $50,325.00 | 183,171 | 2025-04-09 | Filing |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $156.77 | 302 | $47,344.54 | 0 | 2026-08-19 | Filing | |
| $155.59 | 102 | $15,870.16 | 302 | 2026-08-19 | Filing | |
| $153.00 | 400 | $61,199.00 | 404 | 2026-08-19 | Filing | |
| $151.80 | 1,998 | $303,292.20 | 804 | 2026-08-19 | Filing | |
| $151.39 | 1,500 | $227,085.00 | 2,802 | 2026-08-19 | Filing |
| No. | Name | Shares | Value | % Port |
|---|---|---|---|---|
| 1. | 960,619 | $146,801,795 | 0.09% | |
| 2. | 918,357 | $140,343,317 | 0% | |
| 3. | 882,400 | $134,848,368 | 2.94% | |
| 4. | 771,901 | $117,961,911 | 7.17% | |
| 5. | 653,172 | $99,817,745 | 0% |
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