| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Deerfield Management James E. Flynn | 17,248,450 | $1,767,103,703 | 20.85% | |
| 2. | Paradigm Biocapital Advisors Senai Asefaw | 5,324,433 | $545,488,161 | +2% | 11.15% |
| 3. | RA Capital Management Peter Kolchinsky | 2,534,145 | $259,623,155 | +35% | 2.75% |
| 4. | Polar Capital Brian Ashford-Russell And Tim Woolley | 1,831,253 | $187,611,870 | +20% | 0.67% |
| 5. | Perceptive Advisors Joseph Edelman | 1,580,505 | $161,922,737 | -6% | 3.17% |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $33.50 | 650,000 | $21,775,000.00 | 650,000 | 2022-11-03 | Filing | |
| $33.50 | 149,253 | $4,999,975.50 | 3,577,267 | 2022-11-03 | Filing | |
| $17.00 | 735,000 | $12,495,000.00 | 3,428,014 | 2021-08-02 | Filing |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $102.88 | 2,111 | $217,179.68 | 324,879 | 2026-05-04 | Filing | |
| $102.10 | 17,353 | $1,771,741.30 | 326,990 | 2026-05-04 | Filing | |
| $101.48 | 7,429 | $753,894.92 | 344,343 | 2026-05-04 | Filing | |
| $99.77 | 1,408 | $140,476.16 | 351,772 | 2026-05-04 | Filing | |
| $98.54 | 1,699 | $167,419.46 | 353,180 | 2026-05-04 | Filing |
| No. | Name | Shares | Value | % Port |
|---|---|---|---|---|
| 1. | 9,274,959 | $950,219,559 | 0.05% | |
| 2. | 4,824,785 | $494,299,250 | 0.01% | |
| 3. | 3,088,349 | $298,705,153 | 0.02% | |
| 4. | 2,500,907 | $256,217,922 | 0.01% | |
| 5. | 2,470,491 | $253,101,802 | 0.05% |
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