| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | 20,853,000 | $23,902 | -4% | 1.96% | |
| 2. | Sivik Global Healthcare Krishen Sud | 35,000 | $3,033 | 1.41% | |
| 3. | OrbiMed Advisors Samuel Isaly | 1,260,091 | $109,212 | +41% | 1.35% |
| 4. | 27,600,000 | $31,273 | 1.08% | ||
| 5. | Tourbillon Capital Partners Jason Karp | 294,723 | $25,544 | -50% | 1.01% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $50.76 | 2,000 | Director | 2,000 | 2015-11-13 | Filing | |
| $18.00 | 215,000 | Large Shareholder, Other | 2,194,841 | 2014-11-12 | Filing | |
| $18.00 | 40,000 | Large Shareholder | 3,077,005 | 2014-11-12 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $76.14 | 7,000 | Officer | 28,192 | 2018-05-14 | Filing | |
| $81.42 | 1,461 | Director | 11,042 | 2018-03-07 | Filing | |
| $81.42 | 66,125 | Director | 500,109 | 2018-03-07 | Filing | |
| $80.38 | 1,098 | Director | 12,503 | 2018-03-06 | Filing | |
| $80.38 | 49,742 | Director | 566,234 | 2018-03-06 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 166,744 | $14,452 | 3.17% | |
| 2. | 60,850 | $5,274 | 2.52% | |
| 3. | 272,500 | $23,618 | 2.11% | |
| 4. | 613,300 | $53,155 | 2.04% | |
| 5. | 168,805 | $14,630 | 2.01% |
