| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Consonance Capital Management Mitchell Blutt | 1,446,333 | $82,441 | +54% | 4.43% |
| 2. | 100,000,000 | $99,400 | +263% | 3.56% | |
| 3. | 15,031,000 | $14,959 | -35% | 1.38% | |
| 4. | Deerfield Management James E. Flynn | 525,040 | $29,927 | 1.07% | |
| 5. | OrbiMed Advisors Samuel Isaly | 1,357,691 | $77,388 | +8% | 0.93% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $50.76 | 2,000 | Director | 2,000 | 2015-11-13 | Filing | |
| $18.00 | 215,000 | Large Shareholder, Other | 2,194,841 | 2014-11-12 | Filing | |
| $18.00 | 40,000 | Large Shareholder | 3,077,005 | 2014-11-12 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $76.14 | 7,000 | Officer | 28,192 | 2018-05-14 | Filing | |
| $81.42 | 1,461 | Director | 11,042 | 2018-03-07 | Filing | |
| $81.42 | 66,125 | Director | 500,109 | 2018-03-07 | Filing | |
| $80.38 | 1,098 | Director | 12,503 | 2018-03-06 | Filing | |
| $80.38 | 49,742 | Director | 566,234 | 2018-03-06 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 31,379 | $1,789 | 1.65% | |
| 2. | 194,470 | $11,085 | 1.38% | |
| 3. | 673,480 | $38,388 | 1.21% | |
| 4. | 159,800 | $9,109 | 0.61% | |
| 5. | 1,244,340 | $70,927 | 0.59% |
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