| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Consonance Capital Management Mitchell Blutt | 943,070 | $75,304 | 4.85% | |
| 2. | 23,031,000 | $25,003 | +11% | 2.19% | |
| 3. | OrbiMed Advisors Samuel Isaly | 1,260,091 | $100,618 | 1.2% | |
| 4. | 27,600,000 | $29,913 | 1.05% | ||
| 5. | Sectoral Asset Management Jerome Pfund And Michael Sjostrom | 84,000 | $6,707 | -14% | 0.74% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $50.76 | 2,000 | Director | 2,000 | 2015-11-13 | Filing | |
| $18.00 | 215,000 | Large Shareholder, Other | 2,194,841 | 2014-11-12 | Filing | |
| $18.00 | 40,000 | Large Shareholder | 3,077,005 | 2014-11-12 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $76.14 | 7,000 | Officer | 28,192 | 2018-05-14 | Filing | |
| $81.42 | 1,461 | Director | 11,042 | 2018-03-07 | Filing | |
| $81.42 | 66,125 | Director | 500,109 | 2018-03-07 | Filing | |
| $80.38 | 1,098 | Director | 12,503 | 2018-03-06 | Filing | |
| $80.38 | 49,742 | Director | 566,234 | 2018-03-06 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 47,475 | $4 | 3.63% | |
| 2. | 272,500 | $21,759 | 3.02% | |
| 3. | 173,170 | $13,828 | 1.83% | |
| 4. | 47,279 | $3,775 | 1.8% | |
| 5. | 667,730 | $53,318 | 1.77% |
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