| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | 21,582,000 | $22,486 | 1.92% | ||
| 2. | Tourbillon Capital Partners Jason Karp | 585,000 | $40,388 | +49% | 1.49% |
| 3. | 27,600,000 | $28,890 | 1.13% | ||
| 4. | OrbiMed Advisors Samuel Isaly | 897,791 | $61,983 | +82% | 0.78% |
| 5. | Endurant Capital Management Vishal Saluja And Pham Quang | 26,961 | $1,861 | -32% | 0.56% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $50.76 | 2,000 | Director | 2,000 | 2015-11-13 | Filing | |
| $18.00 | 215,000 | Large Shareholder, Other | 2,194,841 | 2014-11-12 | Filing | |
| $18.00 | 40,000 | Large Shareholder | 3,077,005 | 2014-11-12 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $81.42 | 1,461 | Director | 11,042 | 2018-03-07 | Filing | |
| $81.42 | 66,125 | Director | 500,109 | 2018-03-07 | Filing | |
| $80.38 | 1,098 | Director | 12,503 | 2018-03-06 | Filing | |
| $80.38 | 49,742 | Director | 566,234 | 2018-03-06 | Filing | |
| $80.19 | 910 | Director | 13,601 | 2018-03-05 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 168,805 | $14,630 | 2.01% | |
| 2. | 38,298 | $3,319 | 1.62% | |
| 3. | 319,900 | $27,725 | 0.15% | |
| 4. | 5,000 | $433 | 0.14% | |
| 5. | 1,382,785 | $119,846 | 0.11% |
