| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Perceptive Advisors Joseph Edelman | 4,777,254 | $587,363 | +2% | 15.7% |
| 2. | Birchview Capital Matthew Strobeck | 48,000 | $5,902 | -4% | 3.8% |
| 3. | Rock Springs Capital Management Kris Jenner, Gordon Bussard, Graham Mcphail | 645,000 | $79,303 | +3% | 2.87% |
| 4. | DAFNA Capital Management Nathan Fischel | 41,008 | $5,042 | -10% | 2.07% |
| 5. | Healthcor Management LP Arthur B Cohen And Joseph Healey | 410,356 | $50,453 | -49% | 1.67% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $5.96 | 22,300 | Large Shareholder | 3,527,700 | 2011-10-12 | Filing | |
| $5.96 | 1,000 | Large Shareholder | 757,600 | 2011-10-12 | Filing | |
| $5.96 | 6,200 | Large Shareholder | 1,236,665 | 2011-10-12 | Filing | |
| $5.73 | 3,800 | Large Shareholder | 3,505,400 | 2011-10-11 | Filing | |
| $5.59 | 44,700 | Large Shareholder | 3,501,600 | 2011-10-10 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $103.30 | 4,123 | Director | 33,636 | 2018-11-12 | Filing | |
| $110.00 | 16,794 | Officer | 135,997 | 2018-11-08 | Filing | |
| $110.00 | 19,501 | Officer | 135,997 | 2018-11-08 | Filing | |
| $110.26 | 15,046 | Officer | 135,997 | 2018-11-07 | Filing | |
| $110.03 | 9,122 | Officer | 135,997 | 2018-11-07 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 3,158,090 | $388,287 | 10.27% | |
| 2. | 23,133 | $2,844 | 2.62% | |
| 3. | 2,700 | $332 | 1.45% | |
| 4. | 152,574 | $18,759 | 1.19% | |
| 5. | 8,987,000 | $15,319 | 1.18% |
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