| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Perceptive Advisors Joseph Edelman | 4,715,250 | $463,226 | -1% | 12.13% |
| 2. | Birchview Capital Matthew Strobeck | 50,000 | $4,912 | -5% | 3.33% |
| 3. | Healthcor Management LP Arthur B Cohen And Joseph Healey | 793,955 | $77,998 | +15% | 2.47% |
| 4. | Rock Springs Capital Management Kris Jenner, Gordon Bussard, Graham Mcphail | 630,400 | $61,930 | +4% | 2.38% |
| 5. | DAFNA Capital Management Nathan Fischel | 45,508 | $4,471 | -17% | 2.09% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $5.96 | 22,300 | Large Shareholder | 3,527,700 | 2011-10-12 | Filing | |
| $5.96 | 1,000 | Large Shareholder | 757,600 | 2011-10-12 | Filing | |
| $5.96 | 6,200 | Large Shareholder | 1,236,665 | 2011-10-12 | Filing | |
| $5.73 | 3,800 | Large Shareholder | 3,505,400 | 2011-10-11 | Filing | |
| $5.59 | 44,700 | Large Shareholder | 3,501,600 | 2011-10-10 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $115.00 | 28,266 | Officer | 78,742 | 2018-08-01 | Filing | |
| $110.00 | 23,022 | Officer | 82,942 | 2018-08-01 | Filing | |
| $105.00 | 23,000 | Officer | 82,942 | 2018-06-20 | Filing | |
| $99.24 | 15,000 | Director | 260,697 | 2018-06-13 | Filing | |
| $100.00 | 2,785 | Officer | 82,942 | 2018-06-14 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 163,500 | $16,061 | 6.16% | |
| 2. | 15,500,000 | $22,520 | 3.12% | |
| 3. | 26,910 | $2,644 | 2.59% | |
| 4. | 89,884 | $8,830 | 1.98% | |
| 5. | 28,819 | $2,831 | 1.87% |
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