| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | OrbiMed Advisors Samuel Isaly | 9,011,437 | $52,807,021 | 1.01% | |
| 2. | VenBio Select Advisor Kurt Von Emster | 7,550,000 | $44,243,000 | 0.66% | |
| 3. | Rock Springs Capital Management Kris Jenner, Gordon Bussard, Graham Mcphail | 4,103,803 | $24,048,286 | +1% | 0.57% |
| 4. | Sarissa Capital Management Alex Denner | 3,997,010 | $23,422,479 | 2.78% | |
| 5. | Marshall Wace LLP Paul Marshall And Ian Wace | 2,523,984 | $14,790,546 | +378% | 0.03% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $3.20 | 14,760 | Director | 8,663,673 | 2022-06-02 | Filing | |
| $3.28 | 80,759 | Director | 8,648,913 | 2022-05-31 | Filing | |
| $3.19 | 75,000 | Director | 8,568,154 | 2022-05-26 | Filing | |
| $3.18 | 90,155 | Director | 8,493,154 | 2022-05-25 | Filing | |
| $3.29 | 100,000 | Director | 8,402,999 | 2022-05-24 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $5.74 | 2,209 | Officer | 30,821 | 2023-01-17 | Filing | |
| $5.74 | 17,346 | Officer, Director | 48,733 | 2023-01-17 | Filing | |
| $5.74 | 3,575 | Officer | 13,619 | 2023-01-17 | Filing | |
| $5.74 | 458 | Officer | 5,930 | 2023-01-17 | Filing | |
| $5.74 | 6,233 | Officer | 180,363 | 2023-01-17 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 7,491,929 | $43,902,704 | 0% | |
| 2. | 5,856,061 | $34,316,517 | 0% | |
| 3. | 4,449,040 | $26,071,374 | 0% | |
| 4. | 4,282,600 | $25,096,036 | 0.33% | |
| 5. | 2,692,848 | $15,779,351 | 0.1% |
