| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Baker Bros. Advisors Julian Baker And Felix Baker | 6,651,429 | $376,470,881 | 2.72% | |
| 2. | VenBio Select Advisor Kurt Von Emster | 6,350,000 | $359,410,000 | -4% | 4.65% |
| 3. | Biotechnology Value Fund / BVF Inc Mark Lampert | 5,502,710 | $311,453,386 | 12.63% | |
| 4. | Siren L.L.C. Raymond Debbane | 3,428,150 | $194,033,290 | 7.59% | |
| 5. | Driehaus Capital Richard Driehaus | 939,094 | $53,152,720 | +1% | 0.38% |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $86.00 | 1,838,621 | $158,121,406.00 | 7,955,916 | 2025-12-11 | Filing | |
| $86.00 | 167,192 | $14,378,512.00 | 701,326 | 2025-12-11 | Filing | |
| $44.00 | 58,780 | $2,586,320.00 | 353,412 | 2025-06-30 | Filing | |
| $44.00 | 115,783 | $5,094,452.00 | 2,219,858 | 2025-06-30 | Filing | |
| $44.00 | 142,604 | $6,274,576.00 | 2,798,795 | 2025-06-30 | Filing |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $78.52 | 6,014 | $472,211.46 | 663,077 | 2025-12-31 | Filing | |
| $77.95 | 23,986 | $1,869,727.89 | 669,091 | 2025-12-31 | Filing | |
| $84.07 | 1,000 | $84,070.00 | 0 | 2025-12-17 | Filing | |
| $83.45 | 4,099 | $342,064.42 | 1,000 | 2025-12-17 | Filing | |
| $82.34 | 7,959 | $655,361.57 | 5,099 | 2025-12-17 | Filing |
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