| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | RA Capital Management Peter Kolchinsky | 1,441,070 | $31,862 | 1.7% | |
| 2. | Biotechnology Value Fund / BVF Inc Mark Lampert | 609,014 | $13,465 | 1.18% | |
| 3. | Ghost Tree Capital Ken Greenberg And David Kim | 225,000 | $4,975 | 1.05% | |
| 4. | Deerfield Management James E. Flynn | 650,000 | $14,372 | 0.51% | |
| 5. | Broadfin Capital Kevin Kotler | 150,000 | $3,317 | 0.48% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $17.00 | 58,824 | Director | 388,766 | 2018-09-10 | Filing | |
| $17.00 | 1,058,824 | Director | 1,359,149 | 2018-09-10 | Filing | |
| $8.61 | 565,065 | Director | 934,484 | 2017-10-12 | Filing | |
| $8.50 | 850,000 | Large Shareholder, Director | 1,441,070 | 2017-10-12 | Filing | |
| $8.50 | 850,000 | Large Shareholder, Director | 1,441,070 | 2017-10-12 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $8.50 | 1,726,000 | Large Shareholder | 0 | 2017-10-12 | Filing | |
| $10.02 | 481 | Large Shareholder | 1,726,000 | 2017-10-12 | Filing | |
| $10.21 | 35,519 | Large Shareholder | 1,726,481 | 2017-10-11 | Filing | |
| $15.36 | 75,123 | Large Shareholder | 1,762,000 | 2017-10-10 | Filing | |
| $14.07 | 57,580 | Large Shareholder | 1,837,123 | 2017-10-10 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 1,284,931 | $28,410 | 21.46% | |
| 2. | 2,579,490 | $57,033 | 16.69% | |
| 3. | 759,181 | $16,785 | 4.48% | |
| 4. | 388,766 | $8,596 | 4.19% | |
| 5. | 1,359,149 | $30,051 | 3.02% |
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