Ionis Pharmaceuticals Inc (IONS)

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Institutional Investors' Holdings

Filing Period:

No.	Name	Shares	Value	% Port
1.	Fmr Llc	21,520,872	$1,088,740,914	0.08%
2.	Vanguard Group Inc	14,203,481	$718,554,104	0.01%
3.	Blackrock Inc.	9,057,530	$458,220,441	0.01%
4.	Bellevue Group Ag	8,713,987	$440,840,602	6.74%
5.	Clearbridge Investments, Llc	4,707,480	$238,151,403	0.2%