| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Casdin Capital Eli Casdin | 3,838,388 | $90,202,118 | +75% | 8.44% |
| 2. | Rock Springs Capital Management Kris Jenner, Gordon Bussard, Graham Mcphail | 1,125,000 | $26,438 | -3% | 0.95% |
| 3. | Deerfield Management James E. Flynn | 995,312 | $23,390 | +141% | 0.84% |
| 4. | Perceptive Advisors Joseph Edelman | 1,343,491 | $31,572 | -39% | 0.72% |
| 5. | Algert Coldiron Investors Peter Algert And Kevin Coldiron | 53,427 | $1,256 | -29% | 0.46% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $4.50 | 44,444 | Officer, Director | 3,550,669 | 2018-04-02 | Filing | |
| $4.50 | 999,514 | Large Shareholder | 7,480,182 | 2018-03-28 | Filing | |
| $4.50 | 111,597 | Large Shareholder | 845,858 | 2018-03-28 | Filing | |
| $6.00 | 66,666 | Large Shareholder, Officer, Director | 3,506,225 | 2016-11-22 | Filing | |
| $6.25 | 15,000 | Director | 34,259 | 2016-11-18 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $21.40 | 3,788 | Officer | 139,841 | 2019-09-17 | Filing | |
| $24.82 | 28,301 | Officer, Director | 3,450,669 | 2019-08-26 | Filing | |
| $24.02 | 11,699 | Officer, Director | 3,478,970 | 2019-08-26 | Filing | |
| $25.68 | 5,000 | Director | 29,259 | 2019-08-22 | Filing | |
| $25.29 | 20,447 | Officer | 122,905 | 2019-08-19 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 170,868 | $3,293 | 2.35% | |
| 2. | 74,460 | $1,435 | 0.73% | |
| 3. | 67,185 | $1,295 | 0.66% | |
| 4. | 51,763 | $1,005 | 0.27% | |
| 5. | 29,658 | $572 | 0.15% |
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