| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | ARK Investment Management Catherine D. Wood | 27,001,138 | $1,128,918 | -3% | 3% |
| 2. | Baker Bros. Advisors Julian Baker And Felix Baker | 15,649,182 | $654,292 | +33% | 2.46% |
| 3. | Casdin Capital Eli Casdin | 12,298,038 | $514,181 | +37% | 15.23% |
| 4. | Perceptive Advisors Joseph Edelman | 7,284,466 | $304,563 | 3.26% | |
| 5. | Deerfield Management James E. Flynn | 163,385,000 | $263,849 | 5.21% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $4.50 | 44,444 | Officer, Director | 3,550,669 | 2018-04-02 | Filing | |
| $4.50 | 999,514 | Large Shareholder | 7,480,182 | 2018-03-28 | Filing | |
| $4.50 | 111,597 | Large Shareholder | 845,858 | 2018-03-28 | Filing | |
| $6.00 | 66,666 | Large Shareholder, Officer, Director | 3,506,225 | 2016-11-22 | Filing | |
| $6.25 | 15,000 | Director | 34,259 | 2016-11-18 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $41.75 | 300 | Officer | 203,052 | 2021-02-25 | Filing | |
| $40.97 | 1,300 | Officer | 203,352 | 2021-02-25 | Filing | |
| $39.65 | 2,300 | Officer | 204,652 | 2021-02-25 | Filing | |
| $38.95 | 1,100 | Officer | 206,952 | 2021-02-25 | Filing | |
| $49.30 | 2,200 | Director | 19,259 | 2021-02-22 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 18,000 | $75,258,000 | 0.16% | |
| 2. | 142,366 | $6,171,566 | 0% | |
| 3. | 34,624 | $1,447,629 | 0% | |
| 4. | 31,203 | $1,304,597 | 0.27% | |
| 5. | 19,400 | $811,114 | 0% |
