| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Baker Bros. Advisors Julian Baker And Felix Baker | 34,251,034 | $2,294,819 | +1% | 17.24% |
| 2. | Matrix Capital Management David Goel And Paul Ferri | 4,616,847 | $309,329 | +15% | 8.78% |
| 3. | Sivik Global Healthcare Krishen Sud | 85,000 | $5,695 | +89% | 2.18% |
| 4. | Armistice Capital Steven Boyd | 428,000 | $28,676 | 1.87% | |
| 5. | Opus Point Partners Management Michael S. Weiss And Lindsay A. Rosenwald | 12,321 | $826 | +10% | 1.79% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $60.94 | 15,000 | Officer, Director, Other | 276,690 | 2018-05-02 | Filing | |
| $132.00 | 2,029 | Large Shareholder, Director | 789,416 | 2017-09-08 | Filing | |
| $132.00 | 85,402 | Large Shareholder, Director | 29,247,347 | 2017-09-08 | Filing | |
| $132.00 | 12,569 | Large Shareholder, Director | 4,386,818 | 2017-09-08 | Filing | |
| $131.80 | 500 | Director | 4,677 | 2017-05-31 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $71.11 | 10,000 | Officer | 32,963 | 2018-07-09 | Filing | |
| $71.34 | 606 | Officer | 8,103 | 2018-07-09 | Filing | |
| $62.43 | 73,900 | Officer | 33,367 | 2018-04-30 | Filing | |
| $62.43 | 6,100 | Officer | 33,367 | 2018-04-30 | Filing | |
| $85.56 | 1,952 | Officer | 10,970 | 2018-02-21 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 125,975 | $8,442 | 3.24% | |
| 2. | 113,200 | $7,584 | 3.17% | |
| 3. | 4,284,594 | $287,067 | 2.82% | |
| 4. | 383,763 | $25,712 | 2.63% | |
| 5. | 39,831 | $2,669 | 1.77% |
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