| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Baker Bros. Advisors Julian Baker And Felix Baker | 34,251,309 | $2,366,080 | +1% | 15.58% |
| 2. | Matrix Capital Management David Goel And Paul Ferri | 4,616,847 | $318,932 | 7.87% | |
| 3. | Rubric Capital Management David Rosen | 794,640 | $54,894 | 5.8% | |
| 4. | 700,000 | $48,356 | 2.9% | ||
| 5. | Opus Point Partners Management Michael S. Weiss And Lindsay A. Rosenwald | 12,345 | $853 | +1% | 2.03% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $68.91 | 500 | Director | 6,668 | 2018-11-08 | Filing | |
| $68.62 | 500 | Director | 6,168 | 2018-11-08 | Filing | |
| $60.94 | 15,000 | Officer, Director, Other | 276,690 | 2018-05-02 | Filing | |
| $132.00 | 2,029 | Large Shareholder, Director | 789,416 | 2017-09-08 | Filing | |
| $132.00 | 85,402 | Large Shareholder, Director | 29,247,347 | 2017-09-08 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $70.00 | 10,000 | Officer | 14,172 | 2018-10-03 | Filing | |
| $70.00 | 10,000 | Officer | 32,324 | 2018-10-03 | Filing | |
| $70.00 | 1,000 | Officer | 12,427 | 2018-10-03 | Filing | |
| $73.21 | 10,000 | Officer | 32,324 | 2018-09-04 | Filing | |
| $70.00 | 10,000 | Officer | 32,324 | 2018-08-21 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 3,808,322 | $263,079 | 6.96% | |
| 2. | 200,000 | $10,593 | 5.03% | |
| 3. | 610,851 | $42,198 | 4.8% | |
| 4. | 49,420 | $3,414 | 3.15% | |
| 5. | 4,615,489 | $318,836 | 3.13% |
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