| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Baker Bros. Advisors Julian Baker And Felix Baker | 31,976,557 | $2,373,620 | 16.14% | |
| 2. | Matrix Capital Management David Goel And Paul Ferri | 1,934,347 | $143,587 | -52% | 3.54% |
| 3. | Armistice Capital Steven Boyd | 428,000 | $31,770 | +88% | 2.1% |
| 4. | Sivik Global Healthcare Krishen Sud | 55,000 | $4,083 | +23% | 2.06% |
| 5. | Opus Point Partners Management Michael S. Weiss And Lindsay A. Rosenwald | 10,659 | $791 | +1% | 1.42% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $68.91 | 500 | Director | 6,668 | 2018-11-08 | Filing | |
| $68.62 | 500 | Director | 6,168 | 2018-11-08 | Filing | |
| $60.94 | 15,000 | Officer, Director, Other | 276,690 | 2018-05-02 | Filing | |
| $132.00 | 2,029 | Large Shareholder, Director | 789,416 | 2017-09-08 | Filing | |
| $132.00 | 85,402 | Large Shareholder, Director | 29,247,347 | 2017-09-08 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $95.00 | 16,835 | Officer | 95,308 | 2019-12-02 | Filing | |
| $95.00 | 3,165 | Officer | 95,308 | 2019-11-29 | Filing | |
| $95.00 | 7,366 | Officer | 17,609 | 2019-12-02 | Filing | |
| $95.00 | 500 | Officer | 17,609 | 2019-11-29 | Filing | |
| $95.00 | 6,582 | Officer | 16,979 | 2019-12-02 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 345,893 | $25,676 | 4.33% | |
| 2. | 32,825 | $2,436,600 | 1.78% | |
| 3. | 152,623 | $11,329 | 1.63% | |
| 4. | 393,730 | $29,227 | 1.27% | |
| 5. | 217,850 | $16,171 | 1.19% |
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