| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Hitchwood Capital Management James Crichton | 410,000 | $96,932 | +25% | 4.71% |
| 2. | Casdin Capital Eli Casdin | 71,500 | $16,904 | +63% | 2.97% |
| 3. | 5,500,000 | $6,081 | 2.74% | ||
| 4. | Opus Point Partners Management Michael S. Weiss And Lindsay A. Rosenwald | 5,506 | $1,302 | -44% | 2.55% |
| 5. | Sivik Global Healthcare Krishen Sud | 20,000 | $4,728 | +34% | 2.2% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $43.87 | 315 | Director | 670 | 2012-04-18 | Filing | |
| $36.54 | 809 | Director | 809 | 2012-01-17 | Filing | |
| $61.68 | 240 | Director | 1,248 | 2011-07-29 | Filing | |
| $71.37 | 99 | Director | 1,008 | 2011-05-03 | Filing | |
| $71.56 | 169 | Director | 909 | 2011-05-02 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $286.65 | 199 | Officer | 8,516 | 2018-06-11 | Filing | |
| $285.24 | 847 | Officer | 8,715 | 2018-06-11 | Filing | |
| $284.30 | 400 | Officer | 9,562 | 2018-06-11 | Filing | |
| $287.27 | 100 | Officer | 70,996 | 2018-06-11 | Filing | |
| $286.61 | 1,000 | Officer | 71,096 | 2018-06-11 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 12,750,000 | $14,092 | 9.81% | |
| 2. | 39,478 | $9,333 | 7.43% | |
| 3. | 52,584 | $12,432 | 6.9% | |
| 4. | 21,364,000 | $23,636 | 6.77% | |
| 5. | 80,202 | $18,961 | 5.78% |
