| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Scopia Capital Matt Sirovich And Jeremy Mindich | 14,762,354 | $289,047 | +24% | 5.56% |
| 2. | Deerfield Management James E. Flynn | 6,609,894 | $129,422 | 4.63% | |
| 3. | VenBio Select Advisor Kurt Von Emster | 4,460,426 | $87,335 | -21% | 4.01% |
| 4. | Paulson & Co John Paulson | 7,170,700 | $140,402 | -7% | 2.62% |
| 5. | Broadfin Capital Kevin Kotler | 410,532 | $8,038 | -70% | 1.18% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $9.48 | 10,000 | Director | 25,448 | 2017-05-10 | Filing | |
| $31.32 | 10,000 | Director | 10,000 | 2015-08-19 | Filing | |
| $9.76 | 6,000 | Director | 6,000 | 2014-08-14 | Filing | |
| $6.50 | 32,075 | Director | 178,406 | 2013-12-13 | Filing | |
| $6.50 | 32,075 | Director | 178,478 | 2013-12-13 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $21.54 | 408,347 | Officer, Director | 546,070 | 2018-11-14 | Filing | |
| $20.63 | 9,904 | Officer | 28,767 | 2018-08-16 | Filing | |
| $18.00 | 8,888 | Officer | 79,530 | 2018-06-08 | Filing | |
| $17.00 | 6,545 | Officer | 88,418 | 2018-06-08 | Filing | |
| $16.17 | 83,353 | Officer, Director | 546,070 | 2018-06-01 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 121,158 | $2,372 | 3.08% | |
| 2. | 917,051 | $17,956 | 1.79% | |
| 3. | 139,313 | $2,728 | 1.77% | |
| 4. | 92,189 | $1,805 | 1.51% | |
| 5. | 994,358 | $19,470 | 1.51% |
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