| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Broadfin Capital Kevin Kotler | 2,564,175 | $36,411 | -16% | 5.67% |
| 2. | Scopia Capital Matt Sirovich And Jeremy Mindich | 15,163,353 | $215,320 | -8% | 4.3% |
| 3. | VenBio Select Advisor Kurt Von Emster | 5,158,683 | $73,253 | +17% | 3.49% |
| 4. | Deerfield Management James E. Flynn | 6,609,894 | $93,860 | +5% | 3.25% |
| 5. | Paulson & Co John Paulson | 7,670,700 | $108,924 | -3% | 2.38% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $9.48 | 10,000 | Director | 25,448 | 2017-05-10 | Filing | |
| $31.32 | 10,000 | Director | 10,000 | 2015-08-19 | Filing | |
| $9.76 | 6,000 | Director | 6,000 | 2014-08-14 | Filing | |
| $6.50 | 32,075 | Director | 178,406 | 2013-12-13 | Filing | |
| $6.50 | 32,075 | Director | 178,478 | 2013-12-13 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $18.00 | 8,888 | Officer | 79,530 | 2018-06-08 | Filing | |
| $17.00 | 6,545 | Officer | 88,418 | 2018-06-08 | Filing | |
| $16.17 | 83,353 | Officer, Director | 546,070 | 2018-06-01 | Filing | |
| $16.11 | 17,931 | Officer | 92,593 | 2018-05-25 | Filing | |
| $16.00 | 30,000 | Officer | 95,408 | 2017-03-01 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 270,775 | $3,845 | 3.78% | |
| 2. | 2,007,212 | $28,502 | 3.51% | |
| 3. | 152,676 | $2,168 | 1.95% | |
| 4. | 101,027 | $1,435 | 1.45% | |
| 5. | 1,320,081 | $18,745 | 1.34% |
