| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Deerfield Management James E. Flynn | 6,609,894 | $109,460 | 3.84% | |
| 2. | VenBio Select Advisor Kurt Von Emster | 5,593,683 | $92,631 | +9% | 3.56% |
| 3. | Broadfin Capital Kevin Kotler | 1,339,575 | $22,183 | -48% | 3.49% |
| 4. | Scopia Capital Matt Sirovich And Jeremy Mindich | 11,912,290 | $197,268 | -22% | 3.44% |
| 5. | Paulson & Co John Paulson | 7,670,700 | $127,027 | 2.59% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $9.48 | 10,000 | Director | 25,448 | 2017-05-10 | Filing | |
| $31.32 | 10,000 | Director | 10,000 | 2015-08-19 | Filing | |
| $9.76 | 6,000 | Director | 6,000 | 2014-08-14 | Filing | |
| $6.50 | 32,075 | Director | 178,406 | 2013-12-13 | Filing | |
| $6.50 | 32,075 | Director | 178,478 | 2013-12-13 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $20.63 | 9,904 | Officer | 28,767 | 2018-08-16 | Filing | |
| $18.00 | 8,888 | Officer | 79,530 | 2018-06-08 | Filing | |
| $17.00 | 6,545 | Officer | 88,418 | 2018-06-08 | Filing | |
| $16.17 | 83,353 | Officer, Director | 546,070 | 2018-06-01 | Filing | |
| $16.11 | 17,931 | Officer | 92,593 | 2018-05-25 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 917,051 | $17,956 | 1.79% | |
| 2. | 24,264 | $475 | 0.2% | |
| 3. | 146,485 | $2,868 | 0% | |
| 4. | 0 | $0 | 0% | |
| 5. | 880 | $17 | 0% |
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