| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Perceptive Advisors Joseph Edelman | 5,865,726 | $466,266 | -1% | 9.26% |
| 2. | Camber Capital Management Stephen Dubois | 730,000 | $58,028 | 2.95% | |
| 3. | Casdin Capital Eli Casdin | 300,000 | $23,847 | 2.19% | |
| 4. | Sectoral Asset Management Jerome Pfund And Michael Sjostrom | 174,594 | $13,878 | -28% | 2.07% |
| 5. | Corriente Advisors Mark Hart Iii | 40,000 | $3,180 | 1.7% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $38.00 | 175,000 | Large Shareholder | 4,889,066 | 2017-12-19 | Filing | |
| $20.00 | 25,000 | Officer | 25,000 | 2015-08-17 | Filing | |
| $22.36 | 1,000 | Officer | 1,500 | 2016-01-07 | Filing | |
| $20.00 | 500 | Officer | 500 | 2015-08-17 | Filing | |
| $20.00 | 5,000 | Director | 26,428 | 2015-08-17 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $69.71 | 1,313 | Officer | 2,595 | 2020-02-18 | Filing | |
| $70.92 | 1,818 | Officer, Director | 1,077,450 | 2020-02-18 | Filing | |
| $70.22 | 2,189 | Officer, Director | 1,079,268 | 2020-02-18 | Filing | |
| $70.48 | 625 | Officer | 2,595 | 2020-02-10 | Filing | |
| $72.40 | 3,937 | Officer | 2,595 | 2020-02-06 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 177,414 | $14,103 | 11.5% | |
| 2. | 258,012 | $20,509 | 9.8% | |
| 3. | 186,756 | $14,845 | 4.53% | |
| 4. | 115,638 | $9,192 | 3.74% | |
| 5. | 46,873 | $3,726 | 2.49% |
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