| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Matrix Capital Management David Goel And Paul Ferri | 10,000,000 | $215,200 | 6.11% | |
| 2. | Nexthera Capital Ori Hershkovitz | 1,421,600 | $30,593 | 4.73% | |
| 3. | Consonance Capital Management Mitchell Blutt | 3,209,200 | $69,062 | 4.45% | |
| 4. | Great Point Partners Jeffrey Jay And David Kroin | 1,334,793 | $28,725 | +49% | 4.06% |
| 5. | Ghost Tree Capital Ken Greenberg And David Kim | 400,000 | $8,608 | 2.53% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $4.95 | 20,000 | Director | 568,273 | 2016-05-11 | Filing | |
| $4.97 | 40,000 | Director | 548,273 | 2016-05-09 | Filing | |
| $4.78 | 50,000 | Director | 494,975 | 2015-12-11 | Filing | |
| $4.99 | 50,000 | Director | 444,975 | 2015-12-10 | Filing | |
| $1.71 | 10,000 | Director | 45,000 | 2014-09-17 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $18.53 | 22,500 | Officer | 328,288 | 2018-09-04 | Filing | |
| $17.79 | 86,200 | Officer, Director | 125,000 | 2018-08-20 | Filing | |
| $18.61 | 3,800 | Officer, Director | 211,200 | 2018-08-20 | Filing | |
| $19.50 | 40,000 | Director | 133,850 | 2018-08-15 | Filing | |
| $20.91 | 34,267 | Officer, Director | 125,000 | 2018-08-09 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 15,966,038 | $343,589 | 67.11% | |
| 2. | 444,534 | $9,566 | 3.67% | |
| 3. | 941,214 | $20,255 | 2.07% | |
| 4. | 75,600 | $1,627 | 2% | |
| 5. | 117,120 | $2,520 | 1.32% |
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