| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Nexthera Capital Ori Hershkovitz | 1,735,030 | $30,745 | +23% | 5.89% |
| 2. | Great Point Partners Jeffrey Jay And David Kroin | 2,075,000 | $36,769 | +56% | 5.73% |
| 3. | Matrix Capital Management David Goel And Paul Ferri | 10,000,000 | $177,200 | 4.37% | |
| 4. | Consonance Capital Management Mitchell Blutt | 3,879,050 | $68,737 | +21% | 3.7% |
| 5. | Opus Point Partners Management Michael S. Weiss And Lindsay A. Rosenwald | 16,475 | $292 | +22% | 0.69% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $4.95 | 20,000 | Director | 568,273 | 2016-05-11 | Filing | |
| $4.97 | 40,000 | Director | 548,273 | 2016-05-09 | Filing | |
| $4.78 | 50,000 | Director | 494,975 | 2015-12-11 | Filing | |
| $4.99 | 50,000 | Director | 444,975 | 2015-12-10 | Filing | |
| $1.71 | 10,000 | Director | 45,000 | 2014-09-17 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $23.92 | 400 | Officer, Director | 90,000 | 2019-01-16 | Filing | |
| $23.28 | 39,600 | Officer, Director | 90,400 | 2019-01-16 | Filing | |
| $23.54 | 1,000 | Officer | 96,011 | 2019-01-10 | Filing | |
| $24.00 | 2,000 | Officer | 97,011 | 2019-01-10 | Filing | |
| $23.50 | 1,560 | Officer | 97,011 | 2019-01-09 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 15,966,038 | $314,051 | 64.68% | |
| 2. | 127,838 | $2,515 | 1.19% | |
| 3. | 25,779 | $507 | 0.26% | |
| 4. | 36,100 | $710 | 0.04% | |
| 5. | 21,408 | $422 | 0.03% |
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