| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Consonance Capital Management Mitchell Blutt | 6,645,113 | $130,709 | +72% | 9.61% |
| 2. | Nexthera Capital Ori Hershkovitz | 307,739 | $6,053 | -83% | 2.49% |
| 3. | Signition LP George Zweig, Shane Haas And Ravi Chander | 88,994 | $1,751,000 | 1.11% | |
| 4. | Pura Vida Investments Efrem Kamen | 86,055 | $1,693 | +26793% | 1.05% |
| 5. | OrbiMed Advisors Samuel Isaly | 2,801,900 | $55,113 | 1.01% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $4.95 | 20,000 | Director | 568,273 | 2016-05-11 | Filing | |
| $4.97 | 40,000 | Director | 548,273 | 2016-05-09 | Filing | |
| $4.78 | 50,000 | Director | 494,975 | 2015-12-11 | Filing | |
| $4.99 | 50,000 | Director | 444,975 | 2015-12-10 | Filing | |
| $1.71 | 10,000 | Director | 45,000 | 2014-09-17 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $22.66 | 200 | Officer, Director | 90,000 | 2019-02-14 | Filing | |
| $22.39 | 39,800 | Officer, Director | 90,200 | 2019-02-14 | Filing | |
| $22.20 | 23,000 | Officer | 316,513 | 2019-02-15 | Filing | |
| $21.66 | 100,000 | Officer | 316,513 | 2019-02-14 | Filing | |
| $22.03 | 50,500 | Director | 15,221 | 2019-02-14 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 15,966,038 | $314,051 | 64.68% | |
| 2. | 589,534 | $9,105 | 5.65% | |
| 3. | 394,250 | $7,755 | 4.76% | |
| 4. | 958,994 | $18,863 | 2.15% | |
| 5. | 345,575 | $6,797 | 2.1% |
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