| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | OrbiMed Advisors Samuel Isaly | 3,912,900 | $83,619 | +40% | 1.29% |
| 2. | Portolan Capital Management George Mccabe | 540,590 | $11,552 | 1.24% | |
| 3. | Signition LP George Zweig, Shane Haas And Ravi Chander | 84,120 | $1,798,000 | -9% | 1.18% |
| 4. | Farallon Capital Thomas Steyer | 3,000,000 | $64,110 | 0.53% | |
| 5. | Opus Point Partners Management Michael S. Weiss And Lindsay A. Rosenwald | 11,440 | $244 | 0.36% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $4.95 | 20,000 | Director | 568,273 | 2016-05-11 | Filing | |
| $4.97 | 40,000 | Director | 548,273 | 2016-05-09 | Filing | |
| $4.78 | 50,000 | Director | 494,975 | 2015-12-11 | Filing | |
| $4.99 | 50,000 | Director | 444,975 | 2015-12-10 | Filing | |
| $1.71 | 10,000 | Director | 45,000 | 2014-09-17 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $16.27 | 303 | Officer | 89,209 | 2019-10-10 | Filing | |
| $17.66 | 26,364 | Officer, Director | 205,149 | 2019-10-02 | Filing | |
| $17.87 | 30,000 | Officer | 324,331 | 2019-10-01 | Filing | |
| $19.20 | 37,227 | Officer, Director | 196,104 | 2019-09-18 | Filing | |
| $18.84 | 1,000 | Officer | 85,453 | 2019-09-10 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 165,951 | $2,935 | 0.06% | |
| 2. | 14,646 | $259 | 0.04% | |
| 3. | 26,100 | $462 | 0.01% | |
| 4. | 10,000 | $179 | 0.01% | |
| 5. | 53,830 | $951 | 0.01% |
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