| No. | Hedge Fund | Shares | Value | Activity | % Port | 
|---|---|---|---|---|---|
| 1. | Opaleye Management James A. Silverman | 2,860,000 | $40,755,000 | +1% | 8.25% | 
| 2. | EcoR1 Capital Oleg Nodelman | 2,030,544 | $28,935,252 | +5% | 1.71% | 
| 3. | Nantahala Capital Management Wilmot B. Harkey And Daniel Mack | 1,175,951 | $16,757,302 | 0.66% | |
| 4. | Divisadero Street Capital William Zolezzi | 497,716 | $7,092,453 | 0.45% | |
| 5. | Renaissance Technologies Jim Simons | 405,900 | $5,784,075 | +49% | 0.01% |