| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Opaleye Management James A. Silverman | 2,860,000 | $62,147,800 | 8.79% | |
| 2. | EcoR1 Capital Oleg Nodelman | 2,030,544 | $44,123,721 | 2.12% | |
| 3. | Nantahala Capital Management Wilmot B. Harkey And Daniel Mack | 1,175,951 | $25,553,415 | 0.89% | |
| 4. | Cannell Capital J. Carlo Cannell | 455,405 | $9,895,951 | +18% | 1.51% |
| 5. | Renaissance Technologies Jim Simons | 324,621 | $7,054,014 | -21% | 0.01% |