| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Opaleye Management James A. Silverman | 2,860,000 | $103,532,000 | 9.38% | |
| 2. | EcoR1 Capital Oleg Nodelman | 2,171,938 | $78,624,156 | 3.82% | |
| 3. | Nantahala Capital Management Wilmot B. Harkey And Daniel Mack | 1,175,951 | $42,569,426 | 1.41% | |
| 4. | Woodline Partners Michael Rockefeller And Karl Kroeker | 310,879 | $11,253,820 | +83% | 0.03% |
| 5. | Marshall Wace LLP Paul Marshall And Ian Wace | 249,182 | $9,020,387 | +202% | 0.01% |