| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Biotechnology Value Fund / BVF Inc Mark Lampert | 8,748,629 | $23,621,298 | 0.65% | |
| 2. | Partner Fund Management Christopher Medlock James | 4,204,953 | $11,353,373 | +2% | 0.44% |
| 3. | Soleus Capital Guy Levy | 4,202,094 | $11,345,654 | +2% | 1.26% |
| 4. | Adage Capital Management Phill Gross And Robert Atchinson | 1,042,531 | $2,814,834 | 0% | |
| 5. | OrbiMed Advisors Samuel Isaly | 921,940 | $2,489,238 | -24% | 0.04% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $2.60 | 3,067 | Officer, Director | 56,542 | 2022-12-30 | Filing | |
| $2.39 | 21,367 | Officer, Director | 53,475 | 2022-12-22 | Filing | |
| $2.60 | 8,302 | Officer | 33,343 | 2022-12-30 | Filing | |
| $4.50 | 500,000 | Large Shareholder | 7,879,583 | 2022-10-27 | Filing | |
| $3.98 | 1,500,000 | Large Shareholder | 7,379,583 | 2022-10-26 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $2.42 | 34,334 | Director | 684,404 | 2022-12-21 | Filing | |
| $2.41 | 37,889 | Director | 718,738 | 2022-12-21 | Filing | |
| $2.53 | 43,617 | Director | 756,627 | 2022-12-20 | Filing | |
| $2.67 | 50,000 | Director | 800,244 | 2022-12-16 | Filing | |
| $2.86 | 50,000 | Director | 850,244 | 2022-12-15 | Filing |
| No. | Name | Shares | Value | % Port |
|---|---|---|---|---|
| 1. | 7,898,583 | $21,326,174 | 0.3% | |
| 2. | 3,870,080 | $10,449,216 | 0% | |
| 3. | 49,530 | $133,731 | 0% | |
| 4. | 43,873 | $118,457 | 0% | |
| 5. | 31,264 | $84,413 | 0% |
