| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | OrbiMed Advisors Samuel Isaly | 844,046 | $59,598 | +33% | 0.52% |
| 2. | Hudson Executive Capital Douglas Braunstein And James Woolery | 750,501 | $52,993 | 3.83% | |
| 3. | Palo Alto Investors William Leland Edwards | 586,999 | $41,448 | +110% | 2.17% |
| 4. | Arrowstreet Capital Peter Rathjens, Bruce Clarke And John Campbell | 469,124 | $33,125 | -7% | 0.04% |
| 5. | 358,100 | $25,285 | +154% | 0% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $78.29 | 950 | Officer | 30,376 | 2020-08-07 | Filing | |
| $73.90 | 15,123 | Officer, Director | 703,024 | 2020-08-05 | Filing | |
| $73.39 | 17,629 | Officer, Director | 687,901 | 2020-08-05 | Filing | |
| $67.99 | 2,248 | Officer, Director | 670,272 | 2020-08-04 | Filing | |
| $67.51 | 15,000 | Officer, Director | 668,024 | 2020-08-03 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $74.41 | 4,077 | Director | 38,413 | 2020-10-27 | Filing | |
| $112.19 | 100 | Officer | 51,149 | 2020-07-13 | Filing | |
| $111.32 | 1,000 | Officer | 51,249 | 2020-07-13 | Filing | |
| $110.40 | 1,338 | Officer | 52,249 | 2020-07-13 | Filing | |
| $109.69 | 2,740 | Officer | 53,587 | 2020-07-13 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 30,930 | $2,183,967 | 0% | |
| 2. | 28,573 | $2,017,540 | 0% | |
| 3. | 19,727 | $1,392,923 | 0.65% | |
| 4. | 3,987,273 | $281,541 | 0% | |
| 5. | 3,873 | $273,000 | 0.04% |
