| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Copernicus Capital Management John W. Rende | 32,544 | $5,666 | -44% | 5.32% |
| 2. | Giverny Capital Francois Rochon | 180,690 | $31,458 | +5% | 3.56% |
| 3. | Healthcor Management LP Arthur B Cohen And Joseph Healey | 453,715 | $78,992 | 2.61% | |
| 4. | OrbiMed Advisors Samuel Isaly | 990,600 | $172,463 | +14% | 2.07% |
| 5. | Partner Fund Management Christopher Medlock James | 522,672 | $90,997 | +4% | 1.33% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $90.10 | 3,000 | Director | 9,042 | 2017-02-03 | Filing | |
| $83.33 | 3,942 | Officer | 3,942 | 2016-11-30 | Filing | |
| $83.47 | 8,928 | Officer | 43,690 | 2016-11-30 | Filing | |
| $84.63 | 3,000 | Director | 6,042 | 2016-11-29 | Filing | |
| $101.07 | 5,000 | Director | 5,000 | 2016-05-24 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $155.87 | 3,800 | Officer | 31,224 | 2018-12-06 | Filing | |
| $160.96 | 1,319 | Director | 28,609 | 2018-11-29 | Filing | |
| $153.18 | 2,600 | Officer | 13,282 | 2018-11-21 | Filing | |
| $153.14 | 5,259 | Officer | 13,282 | 2018-11-20 | Filing | |
| $150.18 | 18,760 | Officer, Director | 43,126 | 2018-11-19 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 645,655 | $112,409 | 6.55% | |
| 2. | 82,105 | $14,294 | 5.22% | |
| 3. | 166,500 | $28,988 | 5.02% | |
| 4. | 106,696 | $18,576 | 4.44% | |
| 5. | 8,373,966 | $1,457,907 | 4.12% |
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