| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Giverny Capital Francois Rochon | 172,508 | $25,112 | +1% | 3.26% |
| 2. | OrbiMed Advisors Samuel Isaly | 870,900 | $126,777 | -16% | 1.51% |
| 3. | Partner Fund Management Christopher Medlock James | 503,245 | $73,257 | -11% | 1.14% |
| 4. | Rock Springs Capital Management Kris Jenner, Gordon Bussard, Graham Mcphail | 165,000 | $24,019 | -14% | 0.92% |
| 5. | Sectoral Asset Management Jerome Pfund And Michael Sjostrom | 40,860 | $5,948 | -69% | 0.66% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $90.10 | 3,000 | Director | 9,042 | 2017-02-03 | Filing | |
| $83.33 | 3,942 | Officer | 3,942 | 2016-11-30 | Filing | |
| $83.47 | 8,928 | Officer | 43,690 | 2016-11-30 | Filing | |
| $84.63 | 3,000 | Director | 6,042 | 2016-11-29 | Filing | |
| $101.07 | 5,000 | Director | 5,000 | 2016-05-24 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $136.73 | 5,500 | Officer | 20,065 | 2018-08-15 | Filing | |
| $137.14 | 8,700 | Officer | 15,983 | 2018-08-15 | Filing | |
| $135.10 | 7,522 | Officer | 24,683 | 2018-08-15 | Filing | |
| $137.86 | 5,169 | Officer | 32,205 | 2018-08-15 | Filing | |
| $136.10 | 3,609 | Officer | 37,374 | 2018-08-15 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 780,096 | $113,559 | 7.48% | |
| 2. | 58,000 | $8,443 | 6.12% | |
| 3. | 2,027,286 | $295,112 | 5.44% | |
| 4. | 92,613 | $13,482 | 4.85% | |
| 5. | 175,000 | $25,475 | 4.77% |
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