| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Giverny Capital Francois Rochon | 172,508 | $25,112 | +1% | 3.26% |
| 2. | OrbiMed Advisors Samuel Isaly | 870,900 | $126,777 | -16% | 1.51% |
| 3. | Partner Fund Management Christopher Medlock James | 503,245 | $73,257 | -11% | 1.14% |
| 4. | Rock Springs Capital Management Kris Jenner, Gordon Bussard, Graham Mcphail | 165,000 | $24,019 | -14% | 0.92% |
| 5. | Sectoral Asset Management Jerome Pfund And Michael Sjostrom | 40,860 | $5,948 | -69% | 0.66% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $90.10 | 3,000 | Director | 9,042 | 2017-02-03 | Filing | |
| $83.33 | 3,942 | Officer | 3,942 | 2016-11-30 | Filing | |
| $83.47 | 8,928 | Officer | 43,690 | 2016-11-30 | Filing | |
| $84.63 | 3,000 | Director | 6,042 | 2016-11-29 | Filing | |
| $101.07 | 5,000 | Director | 5,000 | 2016-05-24 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $142.64 | 6,300 | Officer | 115,650 | 2018-10-15 | Filing | |
| $142.64 | 328 | Officer | 3,614 | 2018-10-15 | Filing | |
| $142.64 | 372 | Officer | 27,772 | 2018-10-15 | Filing | |
| $147.50 | 5,500 | Officer | 19,990 | 2018-10-10 | Filing | |
| $152.79 | 3,800 | Officer | 77,865 | 2018-10-05 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 342,191 | $59,575 | 2.56% | |
| 2. | 48,152 | $8,386 | 2.54% | |
| 3. | 92,181 | $16,049 | 2.52% | |
| 4. | 13,766 | $2,397 | 2.09% | |
| 5. | 143,300 | $24,949 | 2% |
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