| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Giverny Capital Francois Rochon | 171,166 | $23,881 | +6% | 3.19% |
| 2. | Pura Vida Investments Efrem Kamen | 25,000 | $3,488,000 | 2.92% | |
| 3. | Sectoral Asset Management Jerome Pfund And Michael Sjostrom | 129,959 | $18,132 | -18% | 1.98% |
| 4. | OrbiMed Advisors Samuel Isaly | 1,024,600 | $142,952 | -9% | 1.77% |
| 5. | Partner Fund Management Christopher Medlock James | 559,995 | $78,131 | -38% | 1.58% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $90.10 | 3,000 | Director | 9,042 | 2017-02-03 | Filing | |
| $83.33 | 3,942 | Officer | 3,942 | 2016-11-30 | Filing | |
| $83.47 | 8,928 | Officer | 43,690 | 2016-11-30 | Filing | |
| $84.63 | 3,000 | Director | 6,042 | 2016-11-29 | Filing | |
| $101.07 | 5,000 | Director | 5,000 | 2016-05-24 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $151.86 | 6,300 | Officer | 116,156 | 2018-06-15 | Filing | |
| $153.22 | 4,000 | Officer | 50,785 | 2018-06-13 | Filing | |
| $150.00 | 5,500 | Officer | 20,012 | 2018-06-13 | Filing | |
| $140.79 | 16,510 | Officer | 16,265 | 2018-06-06 | Filing | |
| $141.62 | 8,490 | Officer | 32,775 | 2018-06-06 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 791,087 | $110,372 | 7.42% | |
| 2. | 2,055,734 | $286,816 | 5.63% | |
| 3. | 93,061 | $12,984 | 5.03% | |
| 4. | 934,768 | $130,419 | 4.74% | |
| 5. | 163,000 | $22,742 | 4.37% |
