| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | OrbiMed Advisors Samuel Isaly | 15,518,492 | $630,516,330 | 11.68% | |
| 2. | Paradigm Biocapital Advisors Senai Asefaw | 10,215,455 | $415,053,937 | +39% | 7.77% |
| 3. | RA Capital Management Peter Kolchinsky | 8,392,730 | $340,996,620 | -20% | 2.96% |
| 4. | Driehaus Capital Richard Driehaus | 4,728,623 | $192,123,952 | +6% | 1.11% |
| 5. | Perceptive Advisors Joseph Edelman | 4,373,974 | $177,714,564 | -2% | 2.67% |