| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Biotechnology Value Fund / BVF Inc Mark Lampert | 3,115,537 | $25,952 | -21% | 1.6% |
| 2. | Perceptive Advisors Joseph Edelman | 2,577,043 | $21,467 | -21% | 0.34% |
| 3. | Renaissance Technologies Jim Simons | 2,350,671 | $19,581 | +7% | 0.01% |
| 4. | Great Point Partners Jeffrey Jay And David Kroin | 1,448,604 | $12,067 | +937% | 0.96% |
| 5. | Point72 Asset Management Steve Cohen | 1,033,406 | $8,608 | +378% | 0.05% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $10.33 | 9,000 | Officer | 9,979 | 2019-03-04 | Filing | |
| $12.00 | 3,000 | Officer | 3,000 | 2015-10-14 | Filing | |
| $12.00 | 5,000 | Officer | 5,000 | 2015-10-14 | Filing | |
| $12.00 | 5,000 | Director | 5,000 | 2015-10-14 | Filing | |
| $12.00 | 10,000 | Director | 147,791 | 2015-10-14 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $15.00 | 36,000 | Officer, Director | 84,306 | 2020-05-12 | Filing | |
| $15.00 | 3,000 | Officer | 5,928 | 2018-12-12 | Filing | |
| $15.00 | 3,000 | Officer | 5,928 | 2018-11-01 | Filing | |
| $15.01 | 1,156 | Officer, Director | 82,063 | 2018-11-02 | Filing | |
| $15.00 | 5,270 | Officer, Director | 82,063 | 2018-11-01 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 87,876 | $732,007 | 0.75% | |
| 2. | 30,931 | $257,656 | 0% | |
| 3. | 4,346 | $36,202 | 0% | |
| 4. | 4,137,309 | $34,464 | 0% | |
| 5. | 2,652,335 | $22,093 | 0% |
