| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Biotechnology Value Fund / BVF Inc Mark Lampert | 4,150,639 | $26,232 | -20% | 3.42% |
| 2. | Great Point Partners Jeffrey Jay And David Kroin | 3,173,288 | $20,055 | +46% | 2.53% |
| 3. | DAFNA Capital Management Nathan Fischel | 185,826 | $1,174 | +197% | 0.58% |
| 4. | Lansdowne Partners Alex Snow | 2,647,981 | $16,735 | 0.24% | |
| 5. | Birchview Capital Matthew Strobeck | 10,000 | $63 | 0.05% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $6.95 | 1,000 | Director | 1,850 | 2015-08-31 | Filing | |
| $6.48 | 200 | Director | 30,000 | 2015-08-20 | Filing | |
| $6.60 | 700 | Director | 29,800 | 2015-08-20 | Filing | |
| $6.60 | 4,980 | Director | 29,100 | 2015-08-20 | Filing | |
| $6.46 | 420 | Director | 24,120 | 2015-08-20 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $7.28 | 1,500 | Officer | 84,067 | 2019-02-07 | Filing | |
| $7.31 | 1,500 | Officer | 85,567 | 2019-01-10 | Filing | |
| $7.11 | 4,000 | Officer, Director | 148,022 | 2019-01-04 | Filing | |
| $7.50 | 4,000 | Officer, Director | 152,022 | 2018-12-06 | Filing | |
| $7.38 | 1,500 | Officer | 87,067 | 2018-12-06 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 875,656 | $5,534 | 3.78% | |
| 2. | 90,783 | $574 | 0.53% | |
| 3. | 175,148 | $1,107 | 0.5% | |
| 4. | 2,456,805 | $15,527 | 0.2% | |
| 5. | 592,778 | $3,746 | 0.09% |
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