| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | OrbiMed Advisors Samuel Isaly | 8,053,298 | $24,804 | +19% | 0.23% |
| 2. | Adams Street Partners Jeffrey Diehl | 3,275,616 | $10,089 | 1.61% | |
| 3. | Biotechnology Value Fund / BVF Inc Mark Lampert | 3,229,426 | $9,947 | +67% | 0.37% |
| 4. | Renaissance Technologies Jim Simons | 663,470 | $2,043 | -17% | 0% |
| 5. | Stonepine Capital Timothy P. Lynch | 316,279 | $974 | 0.52% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $2.80 | 35,714 | Officer, Director | 35,714 | 2021-05-04 | Filing | |
| $3.50 | 1,285,714 | Large Shareholder, Director | 8,053,298 | 2021-02-17 | Filing | |
| $3.50 | 1,285,714 | Large Shareholder, Director | 8,053,298 | 2021-02-17 | Filing | |
| $3.50 | 100,000 | Officer, Director | 1,278,515 | 2021-02-17 | Filing | |
| $3.00 | 14,736 | Officer, Director | 1,178,515 | 2019-11-13 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $5.37 | 741,440 | Large Shareholder | 1,389,498 | 2020-07-08 | Filing | |
| $5.25 | 796,622 | Large Shareholder | 2,130,938 | 2020-07-07 | Filing | |
| $4.00 | 1,400,000 | Large Shareholder | 2,927,560 | 2019-07-25 | Filing | |
| $5.01 | 53,240 | Large Shareholder | 4,327,560 | 2019-07-24 | Filing | |
| $5.32 | 39,716 | Large Shareholder | 4,380,800 | 2019-07-23 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 1,000,119 | $3,081 | 0% | |
| 2. | 679,132 | $2,092 | 0.41% | |
| 3. | 416,649 | $1,283 | 0% | |
| 4. | 348,756 | $1,074 | 0% | |
| 5. | 336,748 | $1,037 | 0% |
