| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Opaleye Management James A. Silverman | 1,750,000 | $25,200 | +3% | 6.52% |
| 2. | Casdin Capital Eli Casdin | 2,025,000 | $29,160 | 4.24% | |
| 3. | Nantahala Capital Management Wilmot B. Harkey And Daniel Mack | 6,679,954 | $96,191 | 3.89% | |
| 4. | Prescott Group Capital Management Phil Frohlich | 1,183,453 | $17,042 | -9% | 3.2% |
| 5. | Driehaus Capital Richard Driehaus | 722,849 | $10,409 | +78% | 0.35% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $3.98 | 10,000 | Director | 348,234 | 2015-08-21 | Filing | |
| $4.83 | 10,000 | Director | 320,340 | 2016-11-15 | Filing | |
| $3.47 | 10,000 | Director | 290,246 | 2015-09-11 | Filing | |
| $3.84 | 10,000 | Director | 280,246 | 2015-08-24 | Filing | |
| $3.97 | 20,000 | Director | 270,246 | 2015-08-14 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $14.90 | 2,400 | Officer, Director | 1,072,679 | 2018-08-15 | Filing | |
| $15.19 | 11,859 | Officer, Director | 1,072,679 | 2018-08-14 | Filing | |
| $15.34 | 10,000 | Director | 98,120 | 2018-07-18 | Filing | |
| $15.52 | 25,000 | Director | 304,157 | 2018-07-19 | Filing | |
| $15.40 | 25,000 | Director | 329,157 | 2018-07-18 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 3,350,000 | $48,240 | 6.07% | |
| 2. | 3,054,825 | $43,989 | 5.66% | |
| 3. | 841,419 | $12,116 | 1.88% | |
| 4. | 107,743 | $1,551 | 0.75% | |
| 5. | 60,007 | $864 | 0.74% |
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