| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Opaleye Management James A. Silverman | 1,750,000 | $30,012 | 7.63% | |
| 2. | Casdin Capital Eli Casdin | 2,025,000 | $34,729 | 4.22% | |
| 3. | Prescott Group Capital Management Phil Frohlich | 1,183,453 | $20,296 | 3.97% | |
| 4. | Nantahala Capital Management Wilmot B. Harkey And Daniel Mack | 6,679,954 | $114,561 | 3.08% | |
| 5. | Sensato Capital Management Ernest Chow And Jonathan Howe | 212,536 | $3,645 | 0.62% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $3.98 | 10,000 | Director | 348,234 | 2015-08-21 | Filing | |
| $4.83 | 10,000 | Director | 320,340 | 2016-11-15 | Filing | |
| $3.47 | 10,000 | Director | 290,246 | 2015-09-11 | Filing | |
| $3.84 | 10,000 | Director | 280,246 | 2015-08-24 | Filing | |
| $3.97 | 20,000 | Director | 270,246 | 2015-08-14 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $22.09 | 3,812 | Officer, Director | 1,072,679 | 2018-12-07 | Filing | |
| $21.75 | 40,000 | Officer, Director | 1,072,679 | 2018-12-06 | Filing | |
| $15.22 | 6,726 | Officer | 151,317 | 2018-11-13 | Filing | |
| $15.57 | 6,727 | Officer | 158,043 | 2018-11-12 | Filing | |
| $17.30 | 26,442 | Officer | 134,453 | 2018-10-03 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 3,350,000 | $57,453 | 7.16% | |
| 2. | 2,749,343 | $47,151 | 4.75% | |
| 3. | 837,548 | $14,364 | 2.31% | |
| 4. | 60,833 | $1,043 | 0.82% | |
| 5. | 107,743 | $1,848 | 0.74% |
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