| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Opaleye Management James A. Silverman | 1,700,600 | $18,706 | 5.34% | |
| 2. | Casdin Capital Eli Casdin | 2,025,000 | $22,275 | +27% | 3.91% |
| 3. | Nantahala Capital Management Wilmot B. Harkey And Daniel Mack | 6,679,954 | $73,479 | 3.31% | |
| 4. | Prescott Group Capital Management Phil Frohlich | 1,298,818 | $14,287 | -40% | 3.1% |
| 5. | Driehaus Capital Richard Driehaus | 407,655 | $4,484 | 0.15% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $3.98 | 10,000 | Director | 348,234 | 2015-08-21 | Filing | |
| $4.83 | 10,000 | Director | 320,340 | 2016-11-15 | Filing | |
| $3.47 | 10,000 | Director | 290,246 | 2015-09-11 | Filing | |
| $3.84 | 10,000 | Director | 280,246 | 2015-08-24 | Filing | |
| $3.97 | 20,000 | Director | 270,246 | 2015-08-14 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $16.58 | 10,206 | Director | 225,668 | 2018-06-21 | Filing | |
| $14.41 | 8,947 | Director | 113,230 | 2018-06-12 | Filing | |
| $14.48 | 1,800 | Officer, Director | 1,072,679 | 2018-06-11 | Filing | |
| $15.35 | 7,207 | Officer, Director | 1,072,679 | 2018-06-08 | Filing | |
| $14.11 | 18,736 | Officer | 153,189 | 2018-05-24 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 3,250,000 | $35,750 | 5.21% | |
| 2. | 3,054,825 | $33,603 | 4.76% | |
| 3. | 633,665 | $6,970 | 1.53% | |
| 4. | 107,743 | $1,185 | 0.61% | |
| 5. | 59,325 | $653 | 0.57% |
