| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Opaleye Management James A. Silverman | 1,750,000 | $25,200 | +3% | 6.52% |
| 2. | Casdin Capital Eli Casdin | 2,025,000 | $29,160 | 4.07% | |
| 3. | Nantahala Capital Management Wilmot B. Harkey And Daniel Mack | 6,679,954 | $96,191 | 3.89% | |
| 4. | Prescott Group Capital Management Phil Frohlich | 1,183,453 | $17,042 | -9% | 3.2% |
| 5. | Driehaus Capital Richard Driehaus | 722,849 | $10,409 | +78% | 0.35% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $3.98 | 10,000 | Director | 348,234 | 2015-08-21 | Filing | |
| $4.83 | 10,000 | Director | 320,340 | 2016-11-15 | Filing | |
| $3.47 | 10,000 | Director | 290,246 | 2015-09-11 | Filing | |
| $3.84 | 10,000 | Director | 280,246 | 2015-08-24 | Filing | |
| $3.97 | 20,000 | Director | 270,246 | 2015-08-14 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $17.30 | 26,442 | Officer | 134,453 | 2018-10-03 | Filing | |
| $16.74 | 13,558 | Officer | 160,895 | 2018-10-03 | Filing | |
| $16.76 | 40,000 | Officer | 134,453 | 2018-10-02 | Filing | |
| $17.43 | 40,000 | Officer, Director | 1,072,679 | 2018-09-28 | Filing | |
| $18.68 | 7,100 | Officer, Director | 1,072,679 | 2018-09-27 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 10,000 | $172 | 0.04% | |
| 2. | 1,470 | $25 | 0% | |
| 3. | 1,851 | $32 | 0% |
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