| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | TPG-AXON Management LP Dinakar Singh | 83,950 | $8,469 | +14% | 10.26% |
| 2. | Sivik Global Healthcare Krishen Sud | 70,000 | $7,062 | -13% | 2.62% |
| 3. | Redmile Group Jeremy Green | 541,500 | $54,627 | +34% | 2.37% |
| 4. | Ardsley Partners Philip Hempleman | 125,000 | $12,623 | -38% | 1.53% |
| 5. | GMT Capital Thomas E. Claugus | 640,500 | $64,614 | 1.31% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $67.00 | 150 | Director | 30,650 | 2016-09-07 | Filing | |
| $56.41 | 17,600 | Director | 29,193 | 2013-12-17 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $102.27 | 4,165 | Officer | 50,037 | 2018-03-12 | Filing | |
| $102.27 | 4,800 | Officer | 65,909 | 2018-03-12 | Filing | |
| $104.13 | 8,750 | Director | 478,335 | 2018-02-08 | Filing | |
| $104.30 | 8,750 | Director | 487,085 | 2018-01-08 | Filing | |
| $100.11 | 5,000 | Officer | 94,658 | 2018-01-02 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 23,775 | $2,541 | 1.7% | |
| 2. | 27,747 | $2,953 | 1.57% | |
| 3. | 11,052 | $1,181 | 0.94% | |
| 4. | 65,000 | $6,947 | 0.85% | |
| 5. | 8,922 | $953 | 0.58% |
