| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Sarissa Capital Management Alex Denner | 461,858 | $134,049 | +12% | 26.87% |
| 2. | Woodford Investment Management Neil Woodford | 279,564 | $81,141 | 9.83% | |
| 3. | 2,451 | $62,891 | +19% | 9.71% | |
| 4. | Sabby Capital Hal Mintz | 152,102 | $44,146 | -17% | 6.82% |
| 5. | Camber Capital Management Stephen Dubois | 450,000 | $130,608 | -13% | 5.02% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $269.91 | 48,000 | Director | 461,858 | 2018-04-25 | Filing | |
| $320.55 | 780 | Officer, Director | 4,879 | 2017-12-29 | Filing | |
| $319.84 | 10,000 | Director | 413,858 | 2017-11-29 | Filing | |
| $316.12 | 20,000 | Director | 403,858 | 2017-11-28 | Filing | |
| $271.35 | 1,402 | Officer, Director | 2,927 | 2017-05-01 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $290.83 | 259 | Officer | 6,553 | 2018-02-27 | Filing | |
| $293.44 | 908 | Officer | 6,553 | 2018-02-23 | Filing | |
| $292.00 | 743 | Officer | 6,553 | 2018-02-20 | Filing | |
| $298.85 | 1,294 | Officer | 7,296 | 2018-02-15 | Filing | |
| $329.65 | 5,832 | Director | 17,707 | 2018-01-09 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 22,032 | $6,395 | 5.86% | |
| 2. | 55,870 | $16,216 | 4.98% | |
| 3. | 26,418 | $7,668,000 | 4.6% | |
| 4. | 403,955 | $117,244 | 4.44% | |
| 5. | 78,746 | $22,855 | 4.4% |
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