| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | RA Capital Management Peter Kolchinsky | 7,266,031 | $206,355,280 | +16% | 3.48% |
| 2. | VenBio Select Advisor Kurt Von Emster | 7,050,000 | $200,220,000 | -8% | 3.51% |
| 3. | OrbiMed Advisors Samuel Isaly | 1,812,886 | $51,485,962 | 1.29% | |
| 4. | Casdin Capital Eli Casdin | 1,775,000 | $50,410,000 | -14% | 4.59% |
| 5. | Polar Capital Brian Ashford-Russell And Tim Woolley | 1,770,387 | $50,278,991 | -2% | 0.26% |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $18.00 | 800,000 | $14,400,000.00 | 4,795,000 | 2021-08-04 | Filing | |
| $18.00 | 300,000 | $5,400,000.00 | 2,514,545 | 2020-06-16 | Filing | |
| $18.00 | 950,000 | $17,100,000.00 | 3,995,000 | 2020-06-16 | Filing |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $45.38 | 6,562 | $297,771.09 | 55,000 | 2025-10-03 | Filing | |
| $40.58 | 2,208 | $89,600.64 | 38,867 | 2025-09-22 | Filing | |
| $41.41 | 15,000 | $621,142.50 | 97,130 | 2025-09-15 | Filing | |
| $45.41 | 1,542 | $70,022.22 | 38,867 | 2025-09-15 | Filing | |
| $38.94 | 20,000 | $778,702.00 | 80,195 | 2025-09-11 | Filing |
| No. | Name | Shares | Value | % Port |
|---|---|---|---|---|
| 1. | 343,549 | $14,968,430 | 0.01% | |
| 2. | 64,055 | $2,790,876 | 0.4% | |
| 3. | 45,923 | $2,000,865 | 0% | |
| 4. | 8,540 | $372,088 | 0.02% | |
| 5. | 8,000 | $348,560 | 0.2% |
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