| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Partner Fund Management Christopher Medlock James | 3,373,460 | $87,575 | +33% | 3.08% |
| 2. | Biotechnology Value Fund / BVF Inc Mark Lampert | 2,752,222 | $71,448 | +6% | 2.81% |
| 3. | EcoR1 Capital Oleg Nodelman | 2,195,892 | $57,005 | +22% | 3.06% |
| 4. | Sectoral Asset Management Jerome Pfund And Michael Sjostrom | 861,160 | $22,356 | -7% | 1.57% |
| 5. | D E Shaw D. E. Shaw | 569,333 | $14,780 | -8% | 0.01% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $39.00 | 5,650,000 | Large Shareholder | 13,913,029 | 2021-01-31 | Filing | |
| $21.57 | 5,000 | Officer | 5,000 | 2020-09-09 | Filing | |
| $23.38 | 32,050 | Officer, Director | 3,231,179 | 2020-08-10 | Filing | |
| $21.44 | 11,655 | Officer, Director | 3,199,129 | 2020-08-07 | Filing | |
| $19.68 | 100 | Officer | 600 | 2020-07-31 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $31.35 | 2,117 | Officer | 6,727 | 2020-12-16 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 37,715 | $979,082 | 0% | |
| 2. | 6,166 | $160,069 | 0% | |
| 3. | 4,538 | $118,000 | 0.01% | |
| 4. | 3,255,091 | $84,501 | 0% | |
| 5. | 2,347,624 | $60,944 | 0% |
