| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | EcoR1 Capital Oleg Nodelman | 7,880,094 | $531,906,345 | -34% | 25.86% |
| 2. | Tang Capital Management Kevin C. Tang | 1,330,879 | $89,834,333 | -34% | 4.08% |
| 3. | Millennium Management Israel Englander | 807,316 | $54,493,830 | +14% | 0.02% |
| 4. | Woodline Partners Michael Rockefeller And Karl Kroeker | 717,014 | $48,398,445 | +39% | 0.15% |
| 5. | 683 Capital Partners Ari Zweiman | 660,000 | $44,550,001 | -30% | 2.19% |