| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | EcoR1 Capital Oleg Nodelman | 3,036,014 | $42,899 | +55% | 4.48% |
| 2. | Frazier Healthcare Partners Alan Frazier | 2,316,447 | $32,731 | 3.71% | |
| 3. | Tang Capital Management Kevin C. Tang | 2,290,827 | $32,369 | +25% | 4.54% |
| 4. | Biotechnology Value Fund / BVF Inc Mark Lampert | 1,690,237 | $23,883 | +80% | 2.22% |
| 5. | Aquilo Capital Management Marc Schneidman | 1,439,079 | $20,334 | 7.92% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $14.05 | 3,600 | Director | 3,600 | 2019-12-10 | Filing | |
| $15.00 | 50,000 | Large Shareholder | 3,033,504 | 2017-01-31 | Filing | |
| $15.00 | 88,709 | Large Shareholder, Director | 297,804 | 2017-01-31 | Filing | |
| $15.00 | 311,291 | Large Shareholder, Director | 1,045,031 | 2017-01-31 | Filing | |
| $15.00 | 16,666 | Director | 287,623 | 2017-01-31 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $76.31 | 454 | Officer, Director | 17,636 | 2019-06-10 | Filing | |
| $75.86 | 1,994 | Officer, Director | 18,090 | 2019-06-10 | Filing | |
| $74.68 | 5,000 | Officer, Director | 20,084 | 2019-06-10 | Filing | |
| $73.70 | 6,440 | Officer, Director | 25,084 | 2019-06-10 | Filing | |
| $72.64 | 8,540 | Officer, Director | 31,524 | 2019-06-10 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 21,688 | $306,451 | 0% | |
| 2. | 14,349 | $202,751 | 0% | |
| 3. | 2,346,214 | $33,152 | 0% | |
| 4. | 2,030,670 | $28,694 | 0% | |
| 5. | 1,955,556 | $27,632 | 0% |
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