| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Consonance Capital Management Mitchell Blutt | 24,476,520 | $98,151 | -1% | 8.86% |
| 2. | Opaleye Management James A. Silverman | 860,000 | $3,448 | 1.1% | |
| 3. | Baker Bros. Advisors Julian Baker And Felix Baker | 22,669,509 | $90,905 | 0.78% | |
| 4. | Broadfin Capital Kevin Kotler | 1,150,449 | $4,613 | -30% | 0.75% |
| 5. | Great Point Partners Jeffrey Jay And David Kroin | 1,056,825 | $4,238 | 0.72% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $3.24 | 10,000 | Officer, Director | 1,135,003 | 2017-11-30 | Filing | |
| $1.37 | 25,000 | Officer, Director | 661,743 | 2016-02-01 | Filing | |
| $2.35 | 20,000 | Officer, Director | 304,400 | 2015-08-11 | Filing | |
| $0.84 | 5,500 | Officer | 6,037 | 2014-11-11 | Filing | |
| $0.88 | 20,000 | Officer, Director | 114,900 | 2014-11-12 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $2.89 | 19,042 | Officer | 18,434 | 2018-04-03 | Filing | |
| $2.91 | 7,900 | Officer | 37,476 | 2018-04-02 | Filing | |
| $3.73 | 44,857 | Officer | 18,434 | 2018-01-31 | Filing | |
| $4.41 | 135,205 | Officer | 141,797 | 2018-01-23 | Filing | |
| $4.03 | 31,519 | Officer | 0 | 2018-01-17 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 43,000 | $129 | 0.11% | |
| 2. | 27,150 | $79,276 | 0.04% | |
| 3. | 10,000 | $30 | 0.02% | |
| 4. | 10,000 | $30 | 0.01% | |
| 5. | 10,000 | $30 | 0.01% |
