| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Eversept Partners Kamran Moghtaderi | 1,263,407 | $17,195 | +27% | 9.51% |
| 2. | Consonance Capital Management Mitchell Blutt | 9,450,763 | $128,625 | +91% | 9.45% |
| 3. | Opaleye Management James A. Silverman | 1,250,000 | $17,012 | -22% | 6.34% |
| 4. | Baker Bros. Advisors Julian Baker And Felix Baker | 42,592,824 | $579,688 | +26% | 4.74% |
| 5. | VenBio Select Advisor Kurt Von Emster | 5,575,000 | $75,876 | +38% | 4.53% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $3.24 | 10,000 | Officer, Director | 1,135,003 | 2017-11-30 | Filing | |
| $1.37 | 25,000 | Officer, Director | 661,743 | 2016-02-01 | Filing | |
| $2.35 | 20,000 | Officer, Director | 304,400 | 2015-08-11 | Filing | |
| $0.84 | 5,500 | Officer | 6,037 | 2014-11-11 | Filing | |
| $0.88 | 20,000 | Officer, Director | 114,900 | 2014-11-12 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $20.78 | 100 | Officer | 354,492 | 2019-04-01 | Filing | |
| $20.05 | 9,442 | Officer | 354,592 | 2019-04-01 | Filing | |
| $20.80 | 1,112 | Officer | 31,260 | 2019-04-01 | Filing | |
| $20.03 | 53,060 | Officer | 32,372 | 2019-04-01 | Filing | |
| $21.70 | 70,673 | Officer, Director | 2,087,428 | 2019-03-04 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 23,600 | $490 | 0.2% | |
| 2. | 101,449 | $2,106 | 0.11% | |
| 3. | 13,000 | $270 | 0.1% | |
| 4. | 41,123 | $854 | 0.06% | |
| 5. | 5,556 | $11,534 | 0.03% |
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