| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Opaleye Management James A. Silverman | 1,750,000 | $5,407 | +1% | 1.39% |
| 2. | Consonance Capital Management Mitchell Blutt | 4,968,663 | $15,353 | -72% | 0.99% |
| 3. | 1,455,000 | $4,496 | 0.7% | ||
| 4. | 1,596,200 | $4,932 | +46% | 0.69% | |
| 5. | Baker Bros. Advisors Julian Baker And Felix Baker | 22,669,509 | $70,049 | 0.52% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $3.24 | 10,000 | Officer, Director | 1,135,003 | 2017-11-30 | Filing | |
| $1.37 | 25,000 | Officer, Director | 661,743 | 2016-02-01 | Filing | |
| $2.35 | 20,000 | Officer, Director | 304,400 | 2015-08-11 | Filing | |
| $0.84 | 5,500 | Officer | 6,037 | 2014-11-11 | Filing | |
| $0.88 | 20,000 | Officer, Director | 114,900 | 2014-11-12 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $3.00 | 26,942 | Officer | 18,434 | 2018-07-02 | Filing | |
| $2.89 | 19,042 | Officer | 18,434 | 2018-04-03 | Filing | |
| $2.91 | 7,900 | Officer | 37,476 | 2018-04-02 | Filing | |
| $3.73 | 44,857 | Officer | 18,434 | 2018-01-31 | Filing | |
| $4.41 | 135,205 | Officer | 141,797 | 2018-01-23 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 5,670,205 | $17,521 | 10.64% | |
| 2. | 500,000 | $1,545 | 4.37% | |
| 3. | 5,261,338 | $16,258 | 3.92% | |
| 4. | 3,886,718 | $12,010 | 1.75% | |
| 5. | 3,321,588 | $10,264 | 1.49% |
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