| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Eversept Partners Kamran Moghtaderi | 995,700 | $16,200 | +117% | 7.79% |
| 2. | Opaleye Management James A. Silverman | 1,600,000 | $26,032 | -9% | 6.62% |
| 3. | Consonance Capital Management Mitchell Blutt | 4,968,663 | $80,840 | 4.35% | |
| 4. | Baker Bros. Advisors Julian Baker And Felix Baker | 34,069,509 | $554,311 | +51% | 3.65% |
| 5. | 1,455,000 | $23,673 | 3.48% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $3.24 | 10,000 | Officer, Director | 1,135,003 | 2017-11-30 | Filing | |
| $1.37 | 25,000 | Officer, Director | 661,743 | 2016-02-01 | Filing | |
| $2.35 | 20,000 | Officer, Director | 304,400 | 2015-08-11 | Filing | |
| $0.84 | 5,500 | Officer | 6,037 | 2014-11-11 | Filing | |
| $0.88 | 20,000 | Officer, Director | 114,900 | 2014-11-12 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $17.96 | 100,000 | Director | 84,547 | 2019-01-10 | Filing | |
| $16.00 | 100,000 | Director | 184,547 | 2019-01-10 | Filing | |
| $18.00 | 98,572 | Director | 0 | 2019-01-10 | Filing | |
| $18.00 | 26,932 | Director | 0 | 2019-01-10 | Filing | |
| $18.92 | 3,173 | Officer | 217,934 | 2019-01-11 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 11,170 | $152 | 0.08% | |
| 2. | 1,430 | $19 | 0% | |
| 3. | 0 | $0 | 0% |
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