| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | 12 West Capital Management Joel Ramin | 700,000 | $83,370 | 9.16% | |
| 2. | Casdin Capital Eli Casdin | 250,000 | $29,775 | +25% | 5.23% |
| 3. | Perceptive Advisors Joseph Edelman | 1,280,802 | $152,543 | -4% | 4.27% |
| 4. | Bridger Management Roberto Mignone | 549,632 | $65,461 | +10% | 3.97% |
| 5. | Opus Point Partners Management Michael S. Weiss And Lindsay A. Rosenwald | 13,680 | $1,629 | -69% | 3.19% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $71.87 | 297,501 | Large Shareholder | 10,554,134 | 2017-05-31 | Filing | |
| $65.35 | 11,500 | Officer | 11,500 | 2017-05-30 | Filing | |
| $37.00 | 27,900 | Director | 27,900 | 2016-10-13 | Filing | |
| $58.36 | 2,000 | Director | 4,000 | 2016-03-09 | Filing | |
| $69.75 | 205,030 | Large Shareholder | 10,256,633 | 2016-02-01 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $101.97 | 100 | Director | 8,891 | 2018-05-31 | Filing | |
| $101.37 | 2,100 | Director | 8,991 | 2018-05-31 | Filing | |
| $100.33 | 10,042 | Director | 11,091 | 2018-05-31 | Filing | |
| $99.38 | 2,758 | Director | 21,133 | 2018-05-31 | Filing | |
| $141.47 | 100 | Officer | 0 | 2018-03-26 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 78,893 | $9,396 | 4.49% | |
| 2. | 1,011,338 | $120,450 | 3.32% | |
| 3. | 246,229 | $29,326 | 2.79% | |
| 4. | 105,099 | $12,517 | 2.66% | |
| 5. | 140,841 | $16,774 | 2.48% |
