| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Ghost Tree Capital Ken Greenberg And David Kim | 210,000 | $20,683 | 6.08% | |
| 2. | 12 West Capital Management Joel Ramin | 735,000 | $72,390 | +5% | 5.96% |
| 3. | Perceptive Advisors Joseph Edelman | 1,846,911 | $181,902 | +45% | 4.76% |
| 4. | Casdin Capital Eli Casdin | 270,000 | $26,592 | +8% | 3.71% |
| 5. | Great Point Partners Jeffrey Jay And David Kroin | 260,100 | $25,617 | 3.62% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $71.87 | 297,501 | Large Shareholder | 10,554,134 | 2017-05-31 | Filing | |
| $65.35 | 11,500 | Officer | 11,500 | 2017-05-30 | Filing | |
| $37.00 | 27,900 | Director | 27,900 | 2016-10-13 | Filing | |
| $58.36 | 2,000 | Director | 4,000 | 2016-03-09 | Filing | |
| $69.75 | 205,030 | Large Shareholder | 10,256,633 | 2016-02-01 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $106.25 | 1,400 | Officer, Director | 151,297 | 2018-07-25 | Filing | |
| $105.83 | 34,995 | Officer, Director | 152,697 | 2018-07-25 | Filing | |
| $104.83 | 7,758 | Officer, Director | 187,692 | 2018-07-25 | Filing | |
| $103.69 | 3,847 | Officer, Director | 195,450 | 2018-07-25 | Filing | |
| $102.51 | 2,000 | Officer, Director | 199,297 | 2018-07-25 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 63,493 | $6,253 | 2.98% | |
| 2. | 195,232 | $19,228 | 2.65% | |
| 3. | 352,200 | $34,688 | 2.5% | |
| 4. | 140,602 | $13,848 | 2.07% | |
| 5. | 26,256 | $2,586 | 1.71% |
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