| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Palo Alto Investors William Leland Edwards | 957,950 | $93,822 | -7% | 6.24% |
| 2. | Baker Bros. Advisors Julian Baker And Felix Baker | 8,258,068 | $808,795 | 5.5% | |
| 3. | Camber Capital Management Stephen Dubois | 850,000 | $83,249 | +113% | 4.37% |
| 4. | Partner Fund Management Christopher Medlock James | 1,446,612 | $141,681 | 4.18% | |
| 5. | Redmile Group Jeremy Green | 1,162,200 | $113,826 | 3.8% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $120.79 | 10,000 | Director | 26,333 | 2018-04-30 | Filing | |
| $116.72 | 10,000 | Officer, Director | 38,725 | 2017-06-14 | Filing | |
| $117.10 | 2,000 | Director | 6,333 | 2017-06-15 | Filing | |
| $117.71 | 160,000 | Director | 980,146 | 2017-06-15 | Filing | |
| $117.63 | 103,200 | Director | 820,146 | 2017-06-15 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $132.78 | 4,500 | Officer | 29,627 | 2019-07-01 | Filing | |
| $132.00 | 578 | Officer | 30,201 | 2019-06-21 | Filing | |
| $120.77 | 22,720 | Director | 7,382,978 | 2019-05-30 | Filing | |
| $120.77 | 2,729 | Director | 952,874 | 2019-05-30 | Filing | |
| $122.31 | 13,213 | Director | 7,405,698 | 2019-05-30 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 255,000 | $24,975 | 9.58% | |
| 2. | 1,348,591 | $132,081 | 2.74% | |
| 3. | 453,887 | $44,454 | 1.93% | |
| 4. | 85,280 | $8,352 | 1.92% | |
| 5. | 80,515 | $7,886 | 1.88% |
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