| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | OrbiMed Advisors Samuel Isaly | 12,532,329 | $180,716 | -5% | 3.42% |
| 2. | Deerfield Management James E. Flynn | 2,076,812 | $29,948 | +19% | 1.22% |
| 3. | Casdin Capital Eli Casdin | 811,039 | $11,695,182 | +48% | 1.16% |
| 4. | RA Capital Management Peter Kolchinsky | 1,000,000 | $14,420 | 0.85% | |
| 5. | DAFNA Capital Management Nathan Fischel | 145,000 | $2,091 | +526% | 0.78% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $19.00 | 203,200 | Large Shareholder, Director | 203,200 | 2019-02-11 | Filing | |
| $19.00 | 50,561 | Large Shareholder, Director | 2,455,853 | 2019-02-11 | Filing | |
| $19.00 | 157,939 | Large Shareholder, Director | 10,434,976 | 2019-02-11 | Filing | |
| $19.00 | 203,200 | Large Shareholder, Director | 203,200 | 2019-02-11 | Filing | |
| $19.00 | 50,561 | Large Shareholder, Director | 2,455,853 | 2019-02-11 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $20.07 | 2,300 | Officer | 593,918 | 2019-12-09 | Filing | |
| $20.02 | 5,156 | Officer | 593,918 | 2019-12-06 | Filing | |
| $20.00 | 1,500 | Officer | 593,918 | 2019-12-05 | Filing | |
| $18.31 | 1,315 | Officer | 175,294 | 2019-12-03 | Filing | |
| $15.92 | 7,500 | Officer | 522,317 | 2019-11-15 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 936,371 | $13,502 | 4.36% | |
| 2. | 185,922 | $2,681 | 1.68% | |
| 3. | 93,125 | $1,343 | 0.05% | |
| 4. | 23,000 | $331 | 0.04% | |
| 5. | 12,526 | $181 | 0.03% |
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