| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | OrbiMed Advisors Samuel Isaly | 13,182,329 | $250,464 | 3.87% | |
| 2. | Deerfield Management James E. Flynn | 1,746,923 | $33,192 | -11% | 1.19% |
| 3. | RA Capital Management Peter Kolchinsky | 1,000,000 | $19,000 | 1.01% | |
| 4. | Casdin Capital Eli Casdin | 551,039 | $10,189,059 | +67% | 0.95% |
| 5. | Highline Capital Management Jacob Doft | 645,782 | $12,270 | -22% | 0.89% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $19.00 | 203,200 | Large Shareholder, Director | 203,200 | 2019-02-11 | Filing | |
| $19.00 | 50,561 | Large Shareholder, Director | 2,455,853 | 2019-02-11 | Filing | |
| $19.00 | 157,939 | Large Shareholder, Director | 10,434,976 | 2019-02-11 | Filing | |
| $19.00 | 203,200 | Large Shareholder, Director | 203,200 | 2019-02-11 | Filing | |
| $19.00 | 50,561 | Large Shareholder, Director | 2,455,853 | 2019-02-11 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $14.68 | 10,000 | Officer | 301,719 | 2019-10-15 | Filing | |
| $20.00 | 400 | Officer | 593,918 | 2019-09-20 | Filing | |
| $20.00 | 4,000 | Officer | 311,719 | 2019-09-20 | Filing | |
| $19.08 | 10,000 | Officer | 311,719 | 2019-09-16 | Filing | |
| $15.00 | 7,500 | Officer | 529,817 | 2019-08-19 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 1,143,462 | $21,726 | 6.14% | |
| 2. | 787,769 | $14,968 | 4.01% | |
| 3. | 225,000 | $4,275 | 0.17% | |
| 4. | 1,381,838 | $26,255 | 0.06% | |
| 5. | 13,224 | $251 | 0.05% |
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