| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Knoll Capital Management Fred Knoll | 2,359,767 | $16,849 | 19.16% | |
| 2. | Opaleye Management James A. Silverman | 450,000 | $3,213 | 1.19% | |
| 3. | Cormorant Asset Management Bihua Chen | 488,534 | $3,488 | -3% | 0.28% |
| 4. | Baker Bros. Advisors Julian Baker And Felix Baker | 2,103,164 | $15,017 | -4% | 0.12% |
| 5. | Adage Capital Management Phill Gross And Robert Atchinson | 2,600,000 | $18,564 | +32% | 0.05% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $5.48 | 5,000 | Director | 75,000 | 2016-09-20 | Filing | |
| $5.50 | 20,000 | Director | 70,000 | 2015-07-31 | Filing | |
| $5.50 | 18,182 | Director | 343,182 | 2015-07-31 | Filing | |
| $4.00 | 25,000 | Director | 25,000 | 2015-01-26 | Filing | |
| $4.00 | 250,000 | Large Shareholder, Director | 315,042 | 2014-12-24 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $0.55 | 179,157 | Large Shareholder | 2,413,163 | 2012-06-29 | Filing | |
| $0.68 | 25,000 | Large Shareholder | 2,592,320 | 2012-06-28 | Filing | |
| $0.85 | 1,000 | Large Shareholder | 2,757,620 | 2012-05-15 | Filing | |
| $0.67 | 140,300 | Large Shareholder | 2,617,320 | 2012-05-16 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 649,123 | $4,635 | 0.52% | |
| 2. | 55,000 | $393,000 | 0.23% | |
| 3. | 270,036 | $1,928 | 0.21% | |
| 4. | 32,301 | $231 | 0.1% | |
| 5. | 25,955 | $185 | 0.07% |
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