Billionaire Tom Steyer’s 5 Stock Picks with Huge Upside Potential

In this article, we will list the 5 stock picks of Billionaire Tom Steyer with huge upside potential. Please visit Billionaire Tom Steyer’s 10 Stock Picks with Huge Upside Potential if you would like to see the extended list and the methodology behind it.

5. Revolution Medicines, Inc. (NASDAQ:RVMD)

Farallon Capital’s Stake: $1.1 Billion

Analyst Upside Potential: 44%

Revolution Medicines, Inc. (NASDAQ:RVMD) has featured in the 13F portfolio of Farallon Capital since the first quarter of 2021. Back then, this position comprised 1.6 million shares. Since then, the fund has gradually added to this stake. Filings for the fourth quarter of 2025 show that the fund owned 14.5 million shares in the company, roughly the same as in the third quarter of 2025. Revolution is a clinical-stage precision oncology company that develops novel targeted therapies for RAS-addicted cancers.

Revolution Medicines, Inc. (NASDAQ:RVMD) is turning heads on Wall Street after posting unprecedented data from the Phase 3 RASolute 302 trial of its lead candidate, daraxonrasib. The trial showed a statistically significant overall survival benefit in metastatic pancreatic cancer, a disease that has seen almost no major therapeutic breakthroughs in decades. Hedge funds are positioning ahead of the ASCO Plenary Session in May, where full data will be presented. Investors are rewarding Revolution for its competitive moat strategy as well. Earlier this month, the stock surged after the company sent a cease-and-desist letter to rival Erasca, alleging patent infringement and trade-secret misappropriation related to their own RAS inhibitor. Hedge funds view this aggressive posture as a sign that Revolution intends to protect its multi-billion dollar pan-RAS monopoly, making it a safer long-term bet compared to smaller biotech competitors.