15 Most Successful Penny Stocks in History

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4. Pharmacyclics, Inc. (NASDAQ:PCYC)

Market Cap: $21 Billion (before acquisition)

The biotech space is full of stories about companies that generated great returns for their investors. One of these stocks is Pharmacyclics, Inc. (NASDAQ:PCYC), which in 2015 was acquired by AbbVie Inc (NYSE:ABBV) for $21 billion. Prior to that, the stock was trading for less than $5 between 2006 and 2009 and it turned out to be a great investment, given the price of $261.25 per share that AbbVie offered in cash and stock.

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