| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | EcoR1 Capital Oleg Nodelman | 4,547,072 | $147,280 | +82% | 10.87% |
| 2. | Biotechnology Value Fund / BVF Inc Mark Lampert | 2,068,098 | $66,986 | +23% | 4.12% |
| 3. | Baker Bros. Advisors Julian Baker And Felix Baker | 428,120 | $13,867 | 0.06% | |
| 4. | Rhenman & Partners Asset Management Henrik Rhenman | 260,000 | $8,421 | -14% | 0.9% |
| 5. | Winton Capital Management David Harding | 183,116 | $5,931 | -15% | 0.15% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $29.87 | 12,641 | Large Shareholder | 5,090,000 | 2019-06-06 | Filing | |
| $29.87 | 14,611 | Large Shareholder | 5,077,359 | 2019-05-02 | Filing | |
| $29.77 | 3,500 | Large Shareholder | 5,062,748 | 2019-03-25 | Filing | |
| $29.96 | 2,000 | Large Shareholder | 5,059,248 | 2019-03-22 | Filing | |
| $29.90 | 1,100 | Large Shareholder | 5,057,248 | 2019-03-18 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $27.10 | 600,000 | Large Shareholder | 606,005 | 2020-04-06 | Filing | |
| $31.84 | 44,771 | Large Shareholder | 1,206,005 | 2020-04-06 | Filing | |
| $29.89 | 50,770 | Large Shareholder | 5,012,430 | 2020-03-20 | Filing | |
| $28.23 | 26,800 | Large Shareholder | 5,063,200 | 2020-03-19 | Filing | |
| $36.68 | 60,876 | Large Shareholder | 1,250,776 | 2020-01-08 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 228,225 | $7,392,207 | 0% | |
| 2. | 8,550,717 | $276,958 | 0.03% | |
| 3. | 8,507,377 | $275,552 | 0.01% | |
| 4. | 7,032 | $227,766 | 0% | |
| 5. | 5,767,269 | $186,802 | 0% |
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