| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | EcoR1 Capital Oleg Nodelman | 2,336,557 | $95,635 | +14% | 9.66% |
| 2. | Redmile Group Jeremy Green | 1,612,798 | $66,012 | -47% | 1.86% |
| 3. | Birchview Capital Matthew Strobeck | 12,300 | $503 | 0.3% | |
| 4. | Marshall Wace LLP Paul Marshall And Ian Wace | 364,291 | $14,910 | +82883% | 0.12% |
| 5. | Millennium Management Israel Englander | 1,655,086 | $67,743 | 0.1% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $29.87 | 12,641 | Large Shareholder | 5,090,000 | 2019-06-06 | Filing | |
| $29.87 | 14,611 | Large Shareholder | 5,077,359 | 2019-05-02 | Filing | |
| $29.77 | 3,500 | Large Shareholder | 5,062,748 | 2019-03-25 | Filing | |
| $29.96 | 2,000 | Large Shareholder | 5,059,248 | 2019-03-22 | Filing | |
| $29.90 | 1,100 | Large Shareholder | 5,057,248 | 2019-03-18 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $41.27 | 40,000 | Officer | 73,629 | 2019-08-21 | Filing | |
| $40.69 | 35,000 | Officer | 56,346 | 2019-08-19 | Filing | |
| $46.03 | 40,000 | Officer | 4,952 | 2018-09-17 | Filing | |
| $48.05 | 1,000 | Large Shareholder | 5,017,848 | 2018-09-14 | Filing | |
| $40.10 | 3,659 | Officer | 4,952 | 2018-08-17 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 499,344 | $20,438 | 2.83% | |
| 2. | 319,792 | $13,089 | 1.44% | |
| 3. | 73,575 | $3,011 | 0.53% | |
| 4. | 275,000 | $11,256 | 0.45% | |
| 5. | 300,000 | $12,279 | 0.37% |
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