| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | EcoR1 Capital Oleg Nodelman | 2,059,429 | $63,966 | +109% | 5.89% |
| 2. | Redmile Group Jeremy Green | 3,036,603 | $94,317 | -2% | 2.75% |
| 3. | Opus Point Partners Management Michael S. Weiss And Lindsay A. Rosenwald | 10,935 | $340 | 0.46% | |
| 4. | Birchview Capital Matthew Strobeck | 12,300 | $382 | 0.23% | |
| 5. | Baker Bros. Advisors Julian Baker And Felix Baker | 428,120 | $13,297 | -3% | 0.08% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $29.87 | 14,611 | Large Shareholder | 5,077,359 | 2019-05-02 | Filing | |
| $29.77 | 3,500 | Large Shareholder | 5,062,748 | 2019-03-25 | Filing | |
| $29.96 | 2,000 | Large Shareholder | 5,059,248 | 2019-03-22 | Filing | |
| $29.90 | 1,100 | Large Shareholder | 5,057,248 | 2019-03-18 | Filing | |
| $29.02 | 38,300 | Large Shareholder | 5,056,148 | 2019-03-15 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $46.03 | 40,000 | Officer | 4,952 | 2018-09-17 | Filing | |
| $48.05 | 1,000 | Large Shareholder | 5,017,848 | 2018-09-14 | Filing | |
| $40.10 | 3,659 | Officer | 4,952 | 2018-08-17 | Filing | |
| $41.10 | 20,739 | Officer | 4,952 | 2018-08-16 | Filing | |
| $41.10 | 106 | Officer | 4,952 | 2018-08-15 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 511,328 | $15,882 | 2.06% | |
| 2. | 500,000 | $15,530 | 0.63% | |
| 3. | 209,907 | $6,519 | 0.62% | |
| 4. | 7,160 | $222 | 0.47% | |
| 5. | 78,791 | $2,447 | 0.42% |
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