| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | VenBio Select Advisor Kurt Von Emster | 2,675,000 | $824,622,250 | -4% | 12.87% |
| 2. | Renaissance Technologies Jim Simons | 2,106,992 | $649,522,424 | +1% | 0.98% |
| 3. | AQR Capital Management Cliff Asness | 908,448 | $273,306,521 | -7% | 0.28% |
| 4. | Arrowstreet Capital Peter Rathjens, Bruce Clarke And John Campbell | 398,230 | $122,762,362 | -27% | 0.1% |
| 5. | Deerfield Management James E. Flynn | 275,226 | $84,843,919 | 1.68% |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $82.83 | 4 | $331.32 | 1,684 | 2019-06-10 | Filing | |
| $114.06 | 6 | $684.36 | 1,686 | 2018-04-20 | Filing | |
| $126.20 | 5 | $631.00 | 1,685 | 2017-11-20 | Filing | |
| $128.35 | 3 | $385.05 | 1,686 | 2017-07-28 | Filing | |
| $130.24 | 3 | $390.72 | 1,683 | 2017-07-17 | Filing |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $301.20 | 1,358 | $409,023.22 | 36,781 | 2025-07-10 | Filing | |
| $300.48 | 7,738 | $2,325,108.05 | 38,139 | 2025-07-10 | Filing | |
| $299.49 | 1,304 | $390,530.00 | 45,877 | 2025-07-10 | Filing | |
| $297.89 | 600 | $178,732.44 | 47,181 | 2025-07-10 | Filing | |
| $288.80 | 100 | $28,880.00 | 36,781 | 2025-06-26 | Filing |
| No. | Name | Shares | Value | % Port |
|---|---|---|---|---|
| 1. | 330,617 | $95,002,797 | 0.11% | |
| 2. | 95,844 | $27,540,773 | 0.49% | |
| 3. | 63,924 | $18,368,562 | 1.15% | |
| 4. | 47,772 | $13,727,284 | 3.82% | |
| 5. | 34,006 | $9,771,624 | 0.01% |
