| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | VenBio Select Advisor Kurt Von Emster | 2,675,000 | $824,622,250 | -4% | 12.87% |
| 2. | Renaissance Technologies Jim Simons | 2,106,992 | $649,522,424 | +1% | 0.98% |
| 3. | AQR Capital Management Cliff Asness | 908,448 | $273,306,521 | -7% | 0.28% |
| 4. | Arrowstreet Capital Peter Rathjens, Bruce Clarke And John Campbell | 398,230 | $122,762,362 | -27% | 0.1% |
| 5. | Deerfield Management James E. Flynn | 275,226 | $84,843,919 | 1.68% |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $82.83 | 4 | $331.32 | 1,684 | 2019-06-10 | Filing | |
| $114.06 | 6 | $684.36 | 1,686 | 2018-04-20 | Filing | |
| $126.20 | 5 | $631.00 | 1,685 | 2017-11-20 | Filing | |
| $128.35 | 3 | $385.05 | 1,686 | 2017-07-28 | Filing | |
| $130.24 | 3 | $390.72 | 1,683 | 2017-07-17 | Filing |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $289.99 | 645 | $187,045.23 | 4,883 | 2025-06-24 | Filing | |
| $289.60 | 3,036 | $879,214.06 | 19,384 | 2025-06-24 | Filing | |
| $282.27 | 200 | $56,454.00 | 36,781 | 2025-06-12 | Filing | |
| $281.56 | 4,557 | $1,283,063.45 | 36,981 | 2025-06-12 | Filing | |
| $280.70 | 1,375 | $385,957.41 | 41,538 | 2025-06-12 | Filing |
| No. | Name | Shares | Value | % Port |
|---|---|---|---|---|
| 1. | 5,446,092 | $1,678,866,729 | 0.04% | |
| 2. | 4,457,135 | $1,374,001,007 | 0.02% | |
| 3. | 2,230,708 | $687,660,355 | 0.03% | |
| 4. | 2,026,416 | $624,683,261 | 0.12% | |
| 5. | 1,223,993 | $377,240,583 | 0.03% |
