| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Biotechnology Value Fund / BVF Inc Mark Lampert | 0 | $0 | 0% | |
| 2. | Polar Capital Brian Ashford-Russell And Tim Woolley | 0 | $0 | 0% | |
| 3. | D E Shaw D. E. Shaw | 0 | $0 | 0% | |
| 4. | Renaissance Technologies Jim Simons | 0 | $0 | 0% |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $42.10 | 5,000 | $210,500.00 | 3,758,200 | 2016-10-31 | Filing | |
| $41.71 | 10,000 | $417,100.00 | 3,753,200 | 2016-10-31 | Filing | |
| $40.04 | 8,300 | $332,332.00 | 3,743,200 | 2016-10-18 | Filing | |
| $40.10 | 27,400 | $1,098,740.00 | 3,734,900 | 2016-10-17 | Filing | |
| $39.89 | 4,300 | $171,527.00 | 3,707,500 | 2016-10-17 | Filing |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $11.88 | 29,884 | $354,944.22 | 1,875,905 | 2016-07-13 | Filing | |
| $12.12 | 8,752 | $106,072.49 | 1,905,789 | 2016-07-12 | Filing | |
| $12.19 | 20,431 | $249,100.88 | 1,914,541 | 2016-07-11 | Filing | |
| $12.03 | 21,869 | $263,149.68 | 1,934,972 | 2016-07-07 | Filing | |
| $12.20 | 59,850 | $730,271.75 | 1,956,841 | 2016-07-06 | Filing |
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