| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Frazier Healthcare Partners Alan Frazier | 8,112,121 | $13,872 | 3.33% | |
| 2. | Prosight Capital Lawrence Hawkins | 2,457,683 | $4,203 | -4% | 1.83% |
| 3. | Broadfin Capital Kevin Kotler | 4,829,832 | $8,259 | -2% | 1.7% |
| 4. | Mangrove Partners Nathaniel August | 3,688,609 | $6,308 | 0.84% | |
| 5. | Vivo Capital Albert Cha And Frank Kung | 2,438,270 | $4,169 | 0.41% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $1.64 | 66,000 | Director | 66,000 | 2018-12-10 | Filing | |
| $1.43 | 30,000 | Officer | 133,252 | 2017-03-08 | Filing | |
| $1.35 | 5,925,926 | Large Shareholder, Director | 5,925,926 | 2017-02-14 | Filing | |
| $17.00 | 4,693 | Other | 2,438,270 | 2015-07-21 | Filing | |
| $17.00 | 215,307 | Other | 2,433,577 | 2015-07-21 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $7.01 | 3,000 | Officer | 0 | 2016-03-22 | Filing | |
| $9.39 | 5,000 | Officer | 0 | 2016-01-22 | Filing | |
| $9.66 | 1,000 | Officer | 156,276 | 2016-01-22 | Filing | |
| $10.32 | 1,000 | Officer | 157,276 | 2016-01-21 | Filing | |
| $9.59 | 1,000 | Officer | 158,276 | 2016-01-20 | Filing |
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