| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Orbis Investment Management William B. Gray | 2,472,480 | $796,608,331 | +97% | 3.36% |
| 2. | Perceptive Advisors Joseph Edelman | 2,035,986 | $655,974,329 | +3% | 12.82% |
| 3. | Baker Bros. Advisors Julian Baker And Felix Baker | 1,753,198 | $564,862,864 | +56% | 3.24% |
| 4. | Deerfield Management James E. Flynn | 963,351 | $310,382,059 | +7% | 3.66% |
| 5. | Driehaus Capital Richard Driehaus | 949,225 | $305,830,803 | +2% | 2.25% |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $1.75 | 14,500 | $25,375.00 | 14,500 | 2023-10-05 | Filing | |
| $1.06 | 10,000 | $10,587.00 | 45,002 | 2023-06-27 | Filing | |
| $0.87 | 8,000 | $6,997.60 | 46,416 | 2023-03-24 | Filing | |
| $0.86 | 35,002 | $30,206.51 | 35,002 | 2023-03-23 | Filing | |
| $0.86 | 35,000 | $30,159.50 | 226,299 | 2023-03-23 | Filing |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $194.30 | 9,100 | $1,768,130.00 | 20,832 | 2025-11-20 | Filing | |
| $193.23 | 977 | $188,788.64 | 29,932 | 2025-11-20 | Filing | |
| $192.53 | 13,339 | $2,568,197.69 | 30,909 | 2025-11-20 | Filing | |
| $190.86 | 1,714 | $327,139.18 | 44,248 | 2025-11-20 | Filing | |
| $192.71 | 2,145 | $413,365.10 | 10,442 | 2025-11-20 | Filing |
| No. | Name | Shares | Value | % Port |
|---|---|---|---|---|
| 1. | 3,458,863 | $1,113,513,848 | 0.53% | |
| 2. | 2,324,929 | $749,068,873 | 0.01% | |
| 3. | 2,160,943 | $696,234,295 | 0.04% | |
| 4. | 1,221,944 | $393,698,137 | 0% | |
| 5. | 884,238 | $284,892,641 | 0.01% |
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