| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Biotechnology Value Fund / BVF Inc Mark Lampert | 6,851,051 | $21,512 | +4% | 0.86% |
| 2. | EcoR1 Capital Oleg Nodelman | 6,117,400 | $19,209 | +1% | 0.6% |
| 3. | Stonepine Capital Timothy P. Lynch | 4,218,069 | $13,245 | +6% | 5.49% |
| 4. | D E Shaw D. E. Shaw | 888,701 | $2,791 | +18% | 0% |
| 5. | Ikarian Capital Neil Shahrestani | 738,372 | $2,319 | +5% | 0.3% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $5.84 | 8,488 | Large Shareholder, Officer, Director | 5,792,530 | 2020-08-28 | Filing | |
| $2.50 | 2,000,000 | Large Shareholder | 5,750,000 | 2019-10-08 | Filing | |
| $2.50 | 60,000 | Large Shareholder, Officer, Director | 4,736,529 | 2019-10-08 | Filing | |
| $2.02 | 10,000 | Director | 20,000 | 2019-02-26 | Filing | |
| $2.00 | 75,000 | Large Shareholder, Officer, Director | 4,676,529 | 2019-02-22 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $3.71 | 34,017 | Officer | 726,823 | 2021-07-14 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 3,687,909 | $11,580 | 0% | |
| 2. | 2,500,000 | $7,850 | 0.32% | |
| 3. | 2,139,290 | $6,715 | 0.02% | |
| 4. | 1,305,588 | $4,100 | 0.83% | |
| 5. | 1,152,309 | $3,619 | 0% |
