| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | RA Capital Management Peter Kolchinsky | 2,097,794 | $434,894 | -19% | 6.02% |
| 2. | 1,315,800 | $272,779 | +17% | 0.05% | |
| 3. | 950,900 | $197,131 | +4% | 0.04% | |
| 4. | 69,636,000 | $120,846 | +7% | 6.14% | |
| 5. | Rock Springs Capital Management Kris Jenner, Gordon Bussard, Graham Mcphail | 455,000 | $94,326 | 1.98% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $139.64 | 700 | Director | 2,800 | 2021-05-19 | Filing | |
| $48.83 | 1,500 | Director | 1,500 | 2020-06-03 | Filing | |
| $3.86 | 1,250 | Officer | 1,373 | 2020-01-31 | Filing | |
| $5.85 | 1,000 | Officer | 74,386 | 2019-05-13 | Filing | |
| $0.53 | 22,000 | Director | 22,000 | 2019-03-27 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $144.43 | 100 | Officer | 3,845 | 2022-01-03 | Filing | |
| $143.64 | 1,003 | Officer | 3,945 | 2022-01-03 | Filing | |
| $142.65 | 800 | Officer | 4,948 | 2022-01-03 | Filing | |
| $141.69 | 800 | Officer | 5,748 | 2022-01-03 | Filing | |
| $140.05 | 500 | Officer | 6,548 | 2022-01-03 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 13,531 | $1,936,000 | 0.01% | |
| 2. | 10,126 | $1,448,727 | 0% | |
| 3. | 23,058 | $3,298 | 0.13% | |
| 4. | 18,582 | $2,666 | 0% | |
| 5. | 16,000 | $2,289 | 0.41% |
