| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Opus Point Partners Management Michael S. Weiss And Lindsay A. Rosenwald | 360,000 | $1,552 | -10% | 3.7% |
| 2. | Sio Capital Michael Castor | 2,303,645 | $9,929 | +6% | 3.4% |
| 3. | Biotechnology Value Fund / BVF Inc Mark Lampert | 3,080,308 | $13,276 | 1.16% | |
| 4. | Bailard Inc Thomas Bailard | 410,000 | $1,767 | +183% | 0.1% |
| 5. | Sectoral Asset Management Jerome Pfund And Michael Sjostrom | 44,539 | $192 | 0.02% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $2.25 | 11,000 | Director | 24,250 | 2017-11-27 | Filing | |
| $3.81 | 5,000 | Director | 24,250 | 2015-01-21 | Filing | |
| $4.26 | 1,500 | Director | 5,350 | 2014-12-31 | Filing | |
| $4.28 | 1,500 | Director | 19,250 | 2014-12-31 | Filing | |
| $6.60 | 950 | Director | 3,850 | 2014-06-30 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $3.58 | 9,500 | Officer | 24,106 | 2018-08-07 | Filing | |
| $2.21 | 11,000 | Director | 13,250 | 2017-11-27 | Filing | |
| $1.75 | 157,352 | Large Shareholder | 3,163,105 | 2015-11-09 | Filing | |
| $1.85 | 7,560 | Large Shareholder | 3,320,457 | 2015-11-06 | Filing | |
| $1.91 | 225,660 | Large Shareholder | 3,328,017 | 2015-11-05 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 5,778,106 | $24,904 | 2.51% | |
| 2. | 5,720,572 | $24,656 | 1.06% | |
| 3. | 250,363 | $1,079 | 0.43% | |
| 4. | 373,889 | $1,611 | 0.23% | |
| 5. | 74,644 | $322 | 0.06% |
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