| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Vivo Capital Albert Cha And Frank Kung | 5,681,397 | $14,203 | -2% | 1.33% |
| 2. | Biotechnology Value Fund / BVF Inc Mark Lampert | 2,221,272 | $5,553 | -18% | 0.6% |
| 3. | Perceptive Advisors Joseph Edelman | 4,400,440 | $11,001 | 0.25% | |
| 4. | Bailard Inc Thomas Bailard | 543,992 | $1,360 | +9% | 0.08% |
| 5. | Dorset Management David M. Knott | 38,590 | $96 | 0.04% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $1.74 | 15,000 | Director | 15,000 | 2019-09-06 | Filing | |
| $2.25 | 11,000 | Director | 24,250 | 2017-11-27 | Filing | |
| $3.81 | 5,000 | Director | 24,250 | 2015-01-21 | Filing | |
| $4.26 | 1,500 | Director | 5,350 | 2014-12-31 | Filing | |
| $4.28 | 1,500 | Director | 19,250 | 2014-12-31 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $3.58 | 9,500 | Officer | 24,106 | 2018-08-07 | Filing | |
| $2.21 | 11,000 | Director | 13,250 | 2017-11-27 | Filing | |
| $1.75 | 157,352 | Large Shareholder | 3,163,105 | 2015-11-09 | Filing | |
| $1.85 | 7,560 | Large Shareholder | 3,320,457 | 2015-11-06 | Filing | |
| $1.91 | 225,660 | Large Shareholder | 3,328,017 | 2015-11-05 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 2,101,533 | $5,254 | 5.96% | |
| 2. | 5,720,572 | $14,301 | 1% | |
| 3. | 2,913,091 | $7,283 | 0.62% | |
| 4. | 34,400 | $86 | 0.11% | |
| 5. | 396,526 | $995 | 0.06% |
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