| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Biotechnology Value Fund / BVF Inc Mark Lampert | 4,130,162 | $17,058 | -19% | 1.05% |
| 2. | Renaissance Technologies Jim Simons | 3,312,486 | $13,681 | +9% | 0.01% |
| 3. | Burrage Capital Management Christiana Goh Bardon | 3,001,150 | $12,395 | -1% | 8.67% |
| 4. | Citadel Investment Group Ken Griffin | 2,778,452 | $11,475 | +164% | 0% |
| 5. | Opaleye Management James A. Silverman | 1,556,000 | $6,426 | 1.29% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $1.60 | 10,000 | Director | 10,000 | 2019-12-19 | Filing | |
| $1.60 | 62,500 | Director | 62,500 | 2019-12-19 | Filing | |
| $1.60 | 12,500 | Officer | 37,500 | 2019-12-19 | Filing | |
| $1.60 | 18,750 | Officer, Director | 361,632 | 2019-12-19 | Filing | |
| $1.74 | 15,000 | Director | 15,000 | 2019-09-06 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $3.58 | 9,500 | Officer | 24,106 | 2018-08-07 | Filing | |
| $2.21 | 11,000 | Director | 13,250 | 2017-11-27 | Filing | |
| $1.75 | 157,352 | Large Shareholder | 3,163,105 | 2015-11-09 | Filing | |
| $1.85 | 7,560 | Large Shareholder | 3,320,457 | 2015-11-06 | Filing | |
| $1.91 | 225,660 | Large Shareholder | 3,328,017 | 2015-11-05 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 8,533,072 | $35,242 | 1.41% | |
| 2. | 6,832,678 | $28,220 | 0% | |
| 3. | 5,657 | $23,363 | 0% | |
| 4. | 4,341,395 | $17,930 | 0.12% | |
| 5. | 2,913,091 | $12,031 | 0.52% |
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