| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Biotechnology Value Fund / BVF Inc Mark Lampert | 4,080,162 | $12,730 | -2% | 0.69% |
| 2. | Renaissance Technologies Jim Simons | 3,125,586 | $9,752 | -6% | 0% |
| 3. | Burrage Capital Management Christiana Goh Bardon | 3,039,038 | $9,482 | +2% | 7.48% |
| 4. | Citadel Investment Group Ken Griffin | 2,732,371 | $8,525 | -2% | 0% |
| 5. | Opaleye Management James A. Silverman | 1,556,000 | $4,855 | 0.94% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $1.60 | 10,000 | Director | 10,000 | 2019-12-19 | Filing | |
| $1.60 | 62,500 | Director | 62,500 | 2019-12-19 | Filing | |
| $1.60 | 12,500 | Officer | 37,500 | 2019-12-19 | Filing | |
| $1.60 | 18,750 | Officer, Director | 361,632 | 2019-12-19 | Filing | |
| $1.74 | 15,000 | Director | 15,000 | 2019-09-06 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $3.58 | 9,500 | Officer | 24,106 | 2018-08-07 | Filing | |
| $2.21 | 11,000 | Director | 13,250 | 2017-11-27 | Filing | |
| $1.75 | 157,352 | Large Shareholder | 3,163,105 | 2015-11-09 | Filing | |
| $1.85 | 7,560 | Large Shareholder | 3,320,457 | 2015-11-06 | Filing | |
| $1.91 | 225,660 | Large Shareholder | 3,328,017 | 2015-11-05 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 26,816 | $83,666 | 0% | |
| 2. | 8,533,072 | $26,623 | 1.12% | |
| 3. | 6,979,687 | $21,778 | 0% | |
| 4. | 5,003,774 | $15,611 | 0.09% | |
| 5. | 3,763,804 | $11,743 | 1.2% |
