| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Sio Capital Michael Castor | 2,183,986 | $8,605 | +134% | 4.75% |
| 2. | Opus Point Partners Management Michael S. Weiss And Lindsay A. Rosenwald | 400,000 | $1,576 | 3.41% | |
| 3. | Biotechnology Value Fund / BVF Inc Mark Lampert | 3,080,308 | $12,136 | 1.18% | |
| 4. | Dorset Management David M. Knott | 21,000 | $83 | +50% | 0.03% |
| 5. | Bailard Inc Thomas Bailard | 145,000 | $571 | 0.03% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $2.25 | 11,000 | Director | 24,250 | 2017-11-27 | Filing | |
| $3.81 | 5,000 | Director | 24,250 | 2015-01-21 | Filing | |
| $4.26 | 1,500 | Director | 5,350 | 2014-12-31 | Filing | |
| $4.28 | 1,500 | Director | 19,250 | 2014-12-31 | Filing | |
| $6.60 | 950 | Director | 3,850 | 2014-06-30 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $3.58 | 9,500 | Officer | 24,106 | 2018-08-07 | Filing | |
| $2.21 | 11,000 | Director | 13,250 | 2017-11-27 | Filing | |
| $1.75 | 157,352 | Large Shareholder | 3,163,105 | 2015-11-09 | Filing | |
| $1.85 | 7,560 | Large Shareholder | 3,320,457 | 2015-11-06 | Filing | |
| $1.91 | 225,660 | Large Shareholder | 3,328,017 | 2015-11-05 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 4,400,439 | $17,338 | 6.12% | |
| 2. | 6,600,660 | $26,007 | 3.35% | |
| 3. | 2,913,091 | $11,478 | 1.29% | |
| 4. | 880,087 | $3,468 | 0.61% | |
| 5. | 250,363 | $986 | 0.48% |
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